Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D00YNI
|
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| Former ID |
DIB020150
|
||||
| Drug Name |
L-(cis)-diltiazem
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C22H26N2O4S
|
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| InChI |
InChI=1S/C22H26N2O4S/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H3/t20-,21+/m0/s1
|
||||
| InChIKey |
HSUGRBWQSSZJOP-LEWJYISDSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | CNGA1 | Target Info | Blocker (channel blocker) | [2] | |
| Cav1.4 | Target Info | Inhibitor (gating inhibitor) | [3] | ||
| CNGA2 | Target Info | Blocker (channel blocker) | [4] | ||
| CNGA3 | Target Info | Inhibitor | [5] | ||
| Cyclic nucleotide-gated channel beta-3 (CNGB3) | Target Info | Blocker (channel blocker) | [6] | ||
| KEGG Pathway | cAMP signaling pathway | ||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction | ||||
| Pathway Interaction Database | Visual signal transduction: Cones | ||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2349). | ||||
| REF 2 | A new subunit of the cyclic nucleotide-gated cation channel in retinal rods. Nature. 1993 Apr 22;362(6422):764-7. | ||||
| REF 3 | Functional characterization of the L-type Ca2+ channel Cav1.4alpha1 from mouse retina. Invest Ophthalmol Vis Sci. 2004 Feb;45(2):708-13. | ||||
| REF 4 | Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons. Nature. 1990 Sep 13;347(6289):184-7. | ||||
| REF 5 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 396). | ||||
| REF 6 | Molecular cloning and functional characterization of a new modulatory cyclic nucleotide-gated channel subunit from mouse retina. J Neurosci. 2000 Feb 15;20(4):1324-32. | ||||
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