Drug General Information
Drug ID
D00YNI
Former ID
DIB020150
Drug Name
L-(cis)-diltiazem
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539490]
Structure
Download
2D MOL
Formula
C22H26N2O4S
InChI
InChI=1S/C22H26N2O4S/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H3/t20-,21+/m0/s1
InChIKey
HSUGRBWQSSZJOP-LEWJYISDSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) CNGA1 Target Info Blocker (channel blocker) [533691]
Cav1.4 Target Info Inhibitor (gating inhibitor) [526945]
CNGA2 Target Info Blocker (channel blocker) [528435]
CNGA3 Target Info Inhibitor [543807]
Cyclic nucleotide-gated channel beta-3 (CNGB3) Target Info Blocker (channel blocker) [525687]
KEGG Pathway cAMP signaling pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction
Pathway Interaction Database Visual signal transduction: Cones
References
Ref 539490(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2349).
Ref 525687Molecular cloning and functional characterization of a new modulatory cyclic nucleotide-gated channel subunit from mouse retina. J Neurosci. 2000 Feb 15;20(4):1324-32.
Ref 526945Functional characterization of the L-type Ca2+ channel Cav1.4alpha1 from mouse retina. Invest Ophthalmol Vis Sci. 2004 Feb;45(2):708-13.
Ref 528435Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons. Nature. 1990 Sep 13;347(6289):184-7.
Ref 533691A new subunit of the cyclic nucleotide-gated cation channel in retinal rods. Nature. 1993 Apr 22;362(6422):764-7.
Ref 543807(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 396).

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