Drug Information
Drug General Information | |||||
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Drug ID |
D00YNI
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Former ID |
DIB020150
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Drug Name |
L-(cis)-diltiazem
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [539490] | ||
Structure |
Download2D MOL |
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Formula |
C22H26N2O4S
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InChI |
InChI=1S/C22H26N2O4S/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H3/t20-,21+/m0/s1
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InChIKey |
HSUGRBWQSSZJOP-LEWJYISDSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | CNGA1 | Target Info | Blocker (channel blocker) | [533691] | |
Cav1.4 | Target Info | Inhibitor (gating inhibitor) | [526945] | ||
CNGA2 | Target Info | Blocker (channel blocker) | [528435] | ||
CNGA3 | Target Info | Inhibitor | [543807] | ||
Cyclic nucleotide-gated channel beta-3 (CNGB3) | Target Info | Blocker (channel blocker) | [525687] | ||
KEGG Pathway | cAMP signaling pathway | ||||
Pathway Interaction Database | Visual signal transduction: Cones | ||||
References | |||||
Ref 525687 | Molecular cloning and functional characterization of a new modulatory cyclic nucleotide-gated channel subunit from mouse retina. J Neurosci. 2000 Feb 15;20(4):1324-32. | ||||
Ref 526945 | Functional characterization of the L-type Ca2+ channel Cav1.4alpha1 from mouse retina. Invest Ophthalmol Vis Sci. 2004 Feb;45(2):708-13. | ||||
Ref 528435 | Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons. Nature. 1990 Sep 13;347(6289):184-7. | ||||
Ref 533691 | A new subunit of the cyclic nucleotide-gated cation channel in retinal rods. Nature. 1993 Apr 22;362(6422):764-7. | ||||
Ref 543807 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 396). |
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