Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T34204
|
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| Former ID |
TTDI03121
|
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| Target Name |
CNGA2
|
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| Gene Name |
CNGA2
|
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| Synonyms |
CNGA2
|
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| Target Type |
Clinical Trial
|
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| Disease | Myeloneuropathy [ICD10: G04.1] | ||||
| UniProt ID | |||||
| Sequence |
MTEKTNGVKSSPANNHNHHAPPAIKANGKDDHRTSSRPHSAADDDTSSELQRLADVDAPQ
QGRSGFRRIVRLVGIIREWANKNFREEEPRPDSFLERFRGPELQTVTTQEGDGKGDKDGE DKGTKKKFELFVLDPAGDWYYCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDY VSDVVYIADLFIRLRTGFLEQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDI HSPEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILVIIHWNACIYYAISKSI GFGVDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIG VLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNK KTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDY ICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANI RSLGYSDLFCLSKDDLMEAVTEYPDAKKVLEERGREILMKEGLLDENEVATSMEVDVQEK LGQLETNMETLYTRFGRLLAEYTGAQQKLKQRITVLETKMKQNNEDDYLSDGMNSPELAA ADEP |
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| Drugs and Mode of Action | |||||
| Drug(s) | dequalinium | Drug Info | Clinical trial | Myeloneuropathy | [1] |
| Inhibitor (gating inhibitor) | all-trans-retinal | Drug Info | [2] | ||
| PIP3 | Drug Info | [3] | |||
| Blocker (channel blocker) | dequalinium | Drug Info | [4] | ||
| L-(cis)-diltiazem | Drug Info | [5] | |||
| References | |||||
| REF 1 | Pharmacological characterisation of the human small conductance calcium-activated potassium channel hSK3 reveals sensitivity to tricyclic antidepressants and antipsychotic phenothiazines. Neuropharmacology. 2001 May;40(6):772-83. | ||||
| REF 2 | All-trans-retinal shuts down rod cyclic nucleotide-gated ion channels: a novel role for photoreceptor retinoids in the response to bright light. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8372-7. Epub 2002 May 28. | ||||
| REF 3 | Interplay between PIP3 and calmodulin regulation of olfactory cyclic nucleotide-gated channels. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15635-40. Epub 2006 Oct 10. | ||||
| REF 4 | State-dependent block of CNG channels by dequalinium. J Gen Physiol. 2004 Mar;123(3):295-304. | ||||
| REF 5 | Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons. Nature. 1990 Sep 13;347(6289):184-7. | ||||
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