Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D00YPW
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| Former ID |
DNC004208
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| Drug Name |
ZAPRINAST
|
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| Drug Type |
Small molecular drug
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| Structure |
|
Download2D MOL |
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| Formula |
C13H13N5O2
|
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| InChI |
InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19)
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| InChIKey |
REZGGXNDEMKIQB-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
623910, 4922459, 4991930, 5366120, 7980297, 8149775, 10321616, 11111979, 11111980, 11113810, 11335759, 11360998, 11364159, 11366721, 11369283, 11372065, 11374721, 11377445, 11461970, 11466363, 11467483, 11485049, 11486026, 11489263, 11490748, 11492846, 11495079, 12013177, 14799300, 14872669, 17405794, 24278072, 26604558, 26612231, 26679920, 26747143, 26747144, 26751987, 26759763, 29224759, 46500428, 46514704, 47424342, 47440230, 47499669, 47515302, 47588975, 47720709, 47721704, 47869778
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| Target and Pathway | |||||
| Target(s) | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1 | Target Info | Inhibitor | [527549] | |
| Type IV phosphodiesterase | Target Info | Inhibitor | [527441] | ||
| CGMP-specific 3',5'-cyclic phosphodiesterase | Target Info | Inhibitor | [525827] | ||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
| PathWhiz Pathway | Purine Metabolism | ||||
| References | |||||
| Ref 539935 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2919). | ||||
| Ref 544527 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000060) | ||||
| Ref 525827 | J Med Chem. 2000 Jun 29;43(13):2523-9.4-(3-Chloro-4-methoxybenzyl)aminophthalazines: synthesis and inhibitory activity toward phosphodiesterase 5. | ||||
| Ref 527441 | J Med Chem. 2005 Feb 24;48(4):1237-43.8-Substituted analogues of 3-(3-cyclopentyloxy-4-methoxy-benzyl)-8-isopropyl-adenine: highly potent and selective PDE4 inhibitors. | ||||
| Ref 527549 | J Med Chem. 2005 May 19;48(10):3449-62.The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases. | ||||
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