Target Information
Target General Infomation | |||||
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Target ID |
T56367
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Former ID |
TTDS00167
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Target Name |
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1
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Synonyms |
61 kDa Cam-PDE; Cam-PDE 1; Cam-PDE 1A; HCam-1; PDE-I
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Target Type |
Successful
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Disease | Acute ischemic stroke [ICD9: 434.91; ICD10: I61-I63] | ||||
Function |
Has a higher affinity for cgmp than for camp.
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BioChemical Class |
Phosphoric diester hydrolases
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Target Validation |
T56367
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EC Number |
EC 3.1.4.17
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Drugs and Mode of Action | |||||
References | |||||
Ref 537150 | Effects of phosphodiesterase inhibitors on contraction induced by endothelin-1 of isolated human prostatic tissue. Urology. 2009 Jun;73(6):1397-401. Epub 2009 Mar 13. | ||||
Ref 539935 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2919). | ||||
Ref 527549 | J Med Chem. 2005 May 19;48(10):3449-62.The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases. | ||||
Ref 533395 | J Med Chem. 1985 May;28(5):537-45.A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity. |
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