Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D01XHU
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| Former ID |
DIB003810
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| Drug Name |
AN-207
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| Synonyms |
D-26232; Doxorubicin-analog-[D-Lys(6)]LHRH conjugate, Tulane University/Zentaris
|
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| Indication | Cancer [ICD9: 140-229; ICD10:C00-C96] | Investigative | [1] | ||
| Company |
Tulane University
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C95H121N19O26
|
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| Canonical SMILES |
c12c(C(=O)c3c(C1=O)cccc3OC)c(c1c(c2O)C[C@](C[C@@H]1O[C@<br />H]1C[C@@H]([C@@H]([C@@H](O1)C)O)N1C=CCC1)(C(=O)COC(=O)C<br />CCC(=O)NCCCC[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1[C@H](<br />C(=O)NCC(=O)N)CCC1)CCCNC(=N)N)CC(C)C)NC(=O)[C@@H](NC(=O<br />)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)CC1<br />)Cc1nc[nH]c1)Cc1c[nH]c2c1cccc2)CO)Cc1ccc(cc1)O)O)O
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| CAS Number |
CAS 179910-83-9
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Gonadotropin-releasing hormone receptor | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| GnRH signaling pathway | |||||
| NetPath Pathway | IL1 Signaling Pathway | ||||
| IL2 Signaling Pathway | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
| Reactome | Hormone ligand-binding receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 256). | ||||
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