Drug Information

Drug General Information
Drug ID
D01ZCR
Former ID
DIB018269
Drug Name
[3H]darifenacin
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540168]
Structure
Download
2D MOL
Formula
C28H30N2O2
InChI
InChI=1S/C28H30N2O2/c29-27(31)28(23-7-3-1-4-8-23,24-9-5-2-6-10-24)25-14-17-30(20-25)16-13-21-11-12-26-22(19-21)15-18-32-26/h1-12,19,25H,13-18,20H2,(H2,29,31)/t25-/m1/s1
InChIKey
HXGBXQDTNZMWGS-RUZDIDTESA-N
PubChem Compound ID
444031
PubChem Substance ID
7979027, 10944518, 14856314, 17397751, 36887144, 46508104, 50070895, 50113277, 50275204, 81145912, 85083117, 85583237, 92719451, 103435149, 104004586, 104631174, 126620787, 126651550, 128126220, 134338376, 135030473, 135650160, 135651146, 136947991, 137004287, 142807983, 144240344, 152047381, 160963842, 163621141, 163686486, 164826587, 175268333, 179149827, 186007015, 196107254, 223541474, 223831811, 226439188, 241032006, 249858507, 251916719, 251917958, 252215250
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M3 Target Info Antagonist [534324]
Muscarinic receptor Target Info Antagonist [534324]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeleton
Insulin secretion
Salivary secretion
Gastric acid secretion
Pancreatic secretionhsa04020:Calcium signaling pathway
cAMP signaling pathway
PI3K-Akt signaling pathway
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
PathWhiz Pathway Gastric Acid ProductionPW000564:Muscle/Heart Contraction
Reactome Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP58:Monoamine GPCRs
Secretion of Hydrochloric Acid in Parietal Cells
References
Ref 540168(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 319).
Ref 534324Characterisation of [3H]-darifenacin as a novel radioligand for the study of muscarinic M3 receptors. J Recept Signal Transduct Res. 1997 Jan-May;17(1-3):177-84.

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