Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D02LXI
|
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| Former ID |
DIB020135
|
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| Drug Name |
Ki16425
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [539925] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C24H25ClN2O5S
|
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| InChI |
InChI=1S/C24H25ClN2O5S/c1-14-4-9-19(20(25)12-14)16(3)31-24(30)26-22-15(2)27-32-23(22)18-7-5-17(6-8-18)13-33-11-10-21(28)29/h4-9,12,16H,10-11,13H2,1-3H3,(H,26,30)(H,28,29)
|
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| InChIKey |
NAKZZTXWHXCEPO-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Lysophosphatidic acid receptor Edg-2 | Target Info | Antagonist | [531748] | |
| G protein coupled receptor 87 | Target Info | Antagonist | [529073] | ||
| LPA2 receptor | Target Info | Antagonist | [526829] | ||
| Lysophosphatidate-3 receptor | Target Info | Antagonist | [526829] | ||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
| Pathway Interaction Database | LPA receptor mediated eventslysophospholipid_pathway:LPA receptor mediated events | ||||
| References | |||||
| Ref 526829 | Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors. Mol Pharmacol. 2003 Oct;64(4):994-1005. | ||||
| Ref 529073 | The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor. Biochem Biophys Res Commun. 2007 Nov 23;363(3):861-6. Epub 2007 Sep 24. | ||||
| Ref 531748 | Targeting lysophosphatidic acid receptor type 1 with Debio 0719 inhibits spontaneous metastasis dissemination of breast cancer cells independently of cell proliferation and angiogenesis. Int J Oncol. 2012 Apr;40(4):1133-41. | ||||
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