Drug General Information |
Drug ID |
D03LPH
|
Former ID |
DNC011609
|
Drug Name |
TRYPTOLINE
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
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2D MOL
3D MOL
|
Formula |
C11H12N2
|
Canonical SMILES |
C1CNCC2=C1C3=CC=CC=C3N2
|
InChI |
1S/C11H12N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-4,12-13H,5-7H2
|
InChIKey |
CFTOTSJVQRFXOF-UHFFFAOYSA-N
|
PubChem Compound ID |
|
Target and Pathway |
Target(s) |
Alpha-2A adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
Amine oxidase [flavin-containing] B |
Target Info |
Inhibitor |
[1]
|
Alpha-2B adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
5-hydroxytryptamine 2A receptor |
Target Info |
Inhibitor |
[2]
|
Amine oxidase [flavin-containing] A |
Target Info |
Inhibitor |
[1]
|
Alpha-2C adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
BioCyc Pathway
|
Superpathway of tryptophan utilization
|
Tryptophan degradation via tryptamine
|
Dopamine degradation
|
Putrescine degradation III
|
Noradrenaline and adrenaline degradationPWY66-401:Superpathway of tryptophan utilization
|
Noradrenaline and adrenaline degradation
|
Serotonin degradation
|
Superpathway of melatonin degradation
|
Melatonin degradation II
|
KEGG Pathway
|
cGMP-PKG signaling pathway
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Neuroactive ligand-receptor interactionhsa00260:Glycine, serine and threonine metabolism
|
Arginine and proline metabolism
|
Histidine metabolism
|
Tyrosine metabolism
|
Phenylalanine metabolism
|
Tryptophan metabolism
|
Drug metabolism - cytochrome P450
|
Metabolic pathways
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Serotonergic synapse
|
Dopaminergic synapse
|
Cocaine addiction
|
Amphetamine addiction
|
Alcoholismhsa04022:cGMP-PKG signaling pathway
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Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
|
Neuroactive ligand-receptor interaction
|
Gap junction
|
Inflammatory mediator regulation of TRP channelshsa00260:Glycine, serine and threonine metabolism
|
NetPath Pathway
|
IL4 Signaling Pathway
|
PANTHER Pathway
|
Alpha adrenergic receptor signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
|
5-Hydroxytryptamine degredation
|
Dopamine receptor mediated signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP04374:5HT2 type receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
Pathway Interaction Database
|
Alpha-synuclein signaling
|
PathWhiz Pathway
|
Histidine Metabolism
|
Tyrosine Metabolism
|
Glycine and Serine Metabolism
|
Reactome
|
Adrenoceptors
|
Adrenaline signalling through Alpha-2 adrenergic receptor
|
Adrenaline,noradrenaline inhibits insulin secretion
|
G alpha (i) signalling events
|
G alpha (z) signalling events
|
Surfactant metabolismR-HSA-390696:Adrenoceptors
|
G alpha (z) signalling eventsR-HSA-390666:Serotonin receptors
|
G alpha (q) signalling eventsR-HSA-181430:Norepinephrine Neurotransmitter Release CycleR-HSA-390696:Adrenoceptors
|
Surfactant metabolism
|
WikiPathways
|
Monoamine GPCRs
|
GPCRs, Class A Rhodopsin-like
|
Platelet Aggregation (Plug Formation)
|
Integration of energy metabolism
|
GPCR ligand binding
|
GPCR downstream signalingWP465:Tryptophan metabolism
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Dopamine metabolism
|
Phase 1 - Functionalization of compoundsWP58:Monoamine GPCRs
|
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
|
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
|
SIDS Susceptibility Pathways
|
Gastrin-CREB signalling pathway via PKC and MAPK
|
GPCR downstream signaling
|
GPCRs, OtherWP706:SIDS Susceptibility Pathways
|
Biogenic Amine Synthesis
|
Oxidative Stress
|
Phase 1 - Functionalization of compounds
|
Neurotransmitter Release Cycle
|
Neurotransmitter Clearance In The Synaptic Cleft
|
Serotonin Transporter ActivityWP58:Monoamine GPCRs
|
References |
REF 1 | Bioorg Med Chem Lett. 2004 Jan 19;14(2):527-9.Binding of an imidazopyridoindole at imidazoline I2 receptors. |
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REF 2 | Bioorg Med Chem Lett. 2003 Dec 15;13(24):4421-5.Binding of beta-carbolines at 5-HT(2) serotonin receptors. |