Drug Information

Drug General Information
Drug ID
D03QWO
Former ID
DCL000771
Drug Name
Dexefaroxan
Synonyms
Dexefaroxan [INN]; (+)-(r)-2-(2-ethyl-2,3-dihydro-2-benzofuranyl)-2-imidazoline; 2-[(2R)-2-ethyl-3H-1-benzofuran-2-yl]-4,5-dihydro-1H-imidazole
Drug Type
Small molecular drug
Indication Parkinson's disease [ICD9: 332; ICD10:G20] Phase 2 [526560]
Schizophrenia [ICD9: 295; ICD10:F20] Discontinued in Phase 2 [536463]
Company
Pierre Fabre
Structure
Download
2D MOL

3D MOL
Formula
C13H16N2O
Canonical SMILES
CCC1(CC2=CC=CC=C2O1)C3=NCCN3
InChI
1S/C13H16N2O/c1-2-13(12-14-7-8-15-12)9-10-5-3-4-6-11(10)16-13/h3-6H,2,7-9H2,1H3,(H,14,15)/t13-/m1/s1
InChIKey
RATZLMXRALDSJW-CYBMUJFWSA-N
CAS Number
CAS 143249-88-1
PubChem Compound ID
208820
PubChem Substance ID
9368682, 11111145, 11113707, 14797846, 14797847, 30413479, 57399545, 75410372, 103065992, 103077010, 113441860, 117518521, 124880025, 134224102, 134339257, 135183187, 160666505, 162791858, 184547949, 198957454, 198981203, 226553685
Target and Pathway
Target(s) Adenosine A2a receptor Target Info Agonist [536463]
Nicotinic acetylcholine receptor Target Info Agonist [536463]
KEGG Pathway Rap1 signaling pathway
Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Parkinson's disease
Alcoholism
Pathway Interaction Database HIF-2-alpha transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Reactome NGF-independant TRKA activation
Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolism
WikiPathways Nucleotide GPCRs
Monoamine Transport
GPCRs, Class A Rhodopsin-like
NGF signalling via TRKA from the plasma membrane
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 526560Effects of the alpha 2-adrenoreceptor antagonist dexefaroxan on neurogenesis in the olfactory bulb of the adult rat in vivo: selective protection against neuronal death. Neuroscience. 2003;117(2):281-91.
Ref 536463The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31.
Ref 536463The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31.

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