| Drug General Information |
| Drug ID |
D03RXH
|
| Former ID |
DNC008510
|
| Drug Name |
SALICYLATE
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Phase 4 |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C7H6O3
|
| Canonical SMILES |
C1=CC=C(C(=C1)C(=O)O)O
|
| InChI |
1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)
|
| InChIKey |
YGSDEFSMJLZEOE-UHFFFAOYSA-N
|
| CAS Number |
CAS 69-72-7
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Carbonic anhydrase VI |
Target Info |
Inhibitor |
[2]
|
|---|
| Carbonic anhydrase XII |
Target Info |
Inhibitor |
[2]
|
| Carbonic anhydrase II |
Target Info |
Inhibitor |
[2]
|
| Carbonic anhydrase |
Target Info |
Inhibitor |
[3]
|
| Carbonic anhydrase IV |
Target Info |
Inhibitor |
[2]
|
| Carbonic anhydrase I |
Target Info |
Inhibitor |
[2]
|
|
KEGG Pathway
|
Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
|
|
Proximal tubule bicarbonate reclamation
|
|
Collecting duct acid secretion
|
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Gastric acid secretion
|
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Pancreatic secretion
|
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Bile secretionhsa00910:Nitrogen metabolism
|
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Proximal tubule bicarbonate reclamationhsa00910:Nitrogen metabolism
|
|
NetPath Pathway
|
TGF_beta_Receptor Signaling PathwayNetPath_16:IL4 Signaling Pathway
|
|
EGFR1 Signaling Pathway
|
|
Pathway Interaction Database
|
C-MYB transcription factor network
|
|
PathWhiz Pathway
|
Gastric Acid Production
|
|
Reactome
|
Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
|
|
Erythrocytes take up oxygen and release carbon dioxide
|
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Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
|
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Reversible hydration of carbon dioxide
|
|
WikiPathways
|
Reversible Hydration of Carbon DioxideWP2770:Reversible Hydration of Carbon Dioxide
|
|
miR-targeted genes in muscle cell - TarBase
|
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miR-targeted genes in leukocytes - TarBase
|
|
miR-targeted genes in epithelium - TarBaseWP2770:Reversible Hydration of Carbon Dioxide
|
|
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
|
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Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide
|
|
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
|
| References |
| REF 1 | ClinicalTrials.gov (NCT01712295) 17% Salicylate Versus 17% Salicylate-Ethyl Pyruvate for Plantar Foot Warts. U.S. National Institutes of Health. |
|---|
| REF 2 | Bioorg Med Chem. 2008 Aug 1;16(15):7424-8. Epub 2008 Jun 13.Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. |
|---|
| REF 3 | Bioorg Med Chem Lett. 2008 Jun 15;18(12):3593-6. Epub 2008 May 4.Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols. |
|---|
