Target General Infomation
Target ID
Former ID
Target Name
Carbonic anhydrase II
Gene Name
CA-II; Carbonate dehydratase II; Carbonic anhydrase C; CA2
Target Type
Disease Arthritis [ICD9: 710-719; ICD10: M00-M25]
Breast cancer [ICD9: 174, 175; ICD10: C50]
Cancer [ICD9: 140-229; ICD10: C00-C96]
Duodenal ulcers [ICD10: K25-K27]
Edema associated with congestive heart failure [ICD9: 428.0, 782.3; ICD10: I50, R60.9]
High blood pressure; Edema [ICD9:401; ICD10: I10-I16, R60.9]
Insomnia [ICD9: 307.41, 307.42, 327.0, 780.51, 780.52; ICD10: F51.0, G47.0]
Open-angle glaucoma [ICD9: 365; ICD10: H40-H42]
Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6.
BioChemical Class
Carbon-oxygen lyases
Target Validation
UniProt ID
EC Number
Drugs and Mode of Action
Drug(s) Benzthiazide Drug Info Approved High blood pressure; Edema [538347], [542133], [551871]
Chlorothiazide Drug Info Approved Edema associated with congestive heart failure [468068], [538352], [551871]
Cyclothiazide Drug Info Approved Edema associated with congestive heart failure [467506], [538463], [551871]
Dorzolamide Drug Info Approved Open-angle glaucoma [536361], [541892]
Ethinamate Drug Info Approved Insomnia [538422], [542348]
MAFENIDE Drug Info Approved Bacterial infection [530765]
SALICYLATE Drug Info Phase 4 Discovery agent [524105]
CG-100649 Drug Info Phase 3 Arthritis [524183], [543067]
Curcumin Drug Info Phase 3 Cancer [532348], [542031]
GUAIACOL Drug Info Phase 3 Discovery agent [523035]
PARABEN Drug Info Phase 3 Discovery agent [524059]
SULTHIAME Drug Info Phase 3 Discovery agent [522025]
PHENOL Drug Info Phase 2/3 Discovery agent [525296]
COUMATE Drug Info Phase 2 Breast cancer [531371]
BUTYLATEDHYDROXYTOLUENE Drug Info Phase 1 Discovery agent [524883]
SULFAMIDE Drug Info Phase 1 Discovery agent [524873]
6-ethoxy-1,3-benzothiazole-2-sulfonamide Drug Info Withdrawn from market Duodenal ulcers [529372]
Inhibitor (2,2-dimethyl-1,3-dioxolan-4-yl)methyl sulfamate Drug Info [528233]
(2-bromophenyl)difluoromethanesulfonamide Drug Info [527782]
(4-bromophenyl)difluoromethanesulfonamide Drug Info [527782]
1,2,4-Triazole Drug Info [551393]
1,4-Dihydro-1-methyl-4-oxo-3-pyridinesulfonamide Drug Info [530978]
1,4-phenylene disulfamate Drug Info [529884]
1-(3,4-dichlorophenyl)-3-hydroxyurea Drug Info [528240]
1-acetamido-5-sulfonamidoindane Drug Info [528160]
1-Benzyl-1,4-dihydro-4-oxo-3-pyridinesulfonamide Drug Info [530978]
1-cyclohexylamido-5-sulfonamidoindane Drug Info [528160]
1-pentafluorophenylamido-5-sulfonamidoindane Drug Info [528160]
1-pentenyl-4-(aminosulfonyl)benzoate Drug Info [527786]
1-valproylamido-5-sulfonamidoindane Drug Info [528160]
2,2,2-Trifluoro-N-(4-sulfamoyl-phenyl)-acetamide Drug Info [527743]
2,2-Dimethyl-N-(4-sulfamoyl-phenyl)-propionamide Drug Info [527743]
2,3-dihydro-1H-indene-5-sulfonamide Drug Info [527262]
2,4-dichloro-5-sulfamoylbenzoic acid Drug Info [530578]
2,4-Disulfamyltrifluoromethylaniline Drug Info [530466]
2,6-di-t-butylphenol Drug Info [529973]
2,6-di-tert-butyl-4-methoxyphenol Drug Info [529973]
2,6-Difluorobenzenesulfonamide Drug Info [551391]
2-(4-chlorobenzyloxyamino)-N-hydroxyacetamide Drug Info [528653]
2-(4-chlorobenzyloxyamino)-N-hydroxyhexanamide Drug Info [528653]
2-(4-chlorobenzyloxyamino)-N-hydroxypropanamide Drug Info [528653]
2-(4-hydroxybenzylideneamino)ethanesulfonamide Drug Info [530416]
2-(4-tert-butylbenzylideneamino)ethanesulfonamide Drug Info [530416]
2-(benzylideneamino)ethanesulfonamide Drug Info [530416]
2-(benzyloxyamino)-N-hydroxyhexanamide Drug Info [528653]
2-(N''-Acetyl-hydrazino)-benzenesulfonamide Drug Info [527482]
2-acetamido-5-sulfonamidoindane Drug Info [528160]
2-Acetylamino-indan-5-sulfonic acid hydrate Drug Info [527262]
2-Amino-benzenesulfonamide Drug Info [530466]
2-Amino-indan-5-sulfonic acid Drug Info [527262]
2-butylamido-5-sulfonamidoindane Drug Info [528160]
2-cyclohexylamido-5-sulfonamidoindane Drug Info [528160]
2-ethylamido-5-sulfonamidoindane Drug Info [528160]
2-Hydrazinocarbonyl-benzenesulfonamide Drug Info [527482]
2-hydrazinylbenzenesulfonamide Drug Info [537461]
2-Hydroxycinnamic acid Drug Info [531068]
2-Mercapto-N-(4-sulfamoyl-phenyl)-benzamide Drug Info [529381]
2-methoxyestradiol 3,17-O,O-bis-sulfamate Drug Info [529303]
2-methoxyestradiol-17-O-sulfamate Drug Info [529303]
2-methoxyestrrone-3-O-sulfamate Drug Info [529303]
2-Morpholin-4-yl-N-(4-sulfamoyl-phenyl)-acetamide Drug Info [527338]
2-nonylamido-5-sulfonamidoindane Drug Info [528160]
2-oxo-2H-thiochromene-3-carboxylic acid Drug Info [530514]
2-pentafluorophenylamido-5-sulfonamidoindane Drug Info [528160]
2-propylamido-5-sulfonamidoindane Drug Info [528160]
2-Sulfamoyl-benzoic acid methyl ester Drug Info [527482]
2-valproylamido-5-sulfonamidoindane Drug Info [528160]
3,5-Difluorobenzenesulfonamide Drug Info [551393]
3-((4-aminophenyl)diazenyl)benzenesulfonamide Drug Info [530292]
3-((4-hydroxyphenyl)diazenyl)benzenesulfonamide Drug Info [530292]
3-(3-Phenyl-ureido)-benzenesulfonamide Drug Info [527743]
3-(4'-Hydroxyphenyl)diazenylbenzenesulfonamide Drug Info [530292]
3-(4-sulfamoylphenyl)propanoic acid Drug Info [530466]
3-Amino-benzenesulfonamide Drug Info [527415]
3-bromophenyl-difluoromethanesulfonamide Drug Info [527782]
3-Chloro-4-hydrazino-benzenesulfonamide Drug Info [527482]
3-Fluoro-4-hydrazino-benzenesulfonamide Drug Info [527482]
3-hydroxy-2-methoxybenzaldehyde Drug Info [529973]
3-mercapto-N-(4-sulfamoyl-phenyl)-propionamide Drug Info [528406]
3-Mercuri-4-Aminobenzenesulfonamide Drug Info [551393]
3-Nitro-benzenesulfonamide Drug Info [527253]
3-phenyl-5-sulfamoyl-1H-indole-2-carboxamide Drug Info [530132]
3-phenylprop-1-enylboronic acid Drug Info [530086]
4,4'-thiodipyridine-3-sulfonamide Drug Info [530766]
4,6-Dinitro salicylic acid Drug Info [529721]
4-((4-hydroxyphenyl)diazenyl)benzenesulfonamide Drug Info [530292]
4-((benzylideneamino)methyl)benzenesulfonamide Drug Info [530416]
4-(2-Amino-ethyl)-benzenesulfonamide Drug Info [527645]
4-(2-aminopyrimidin-4-ylamino)benzenesulfonamide Drug Info [530466]
4-(2-Hydroxy-ethyl)-benzenesulfonamide Drug Info [531031]
4-(2-Methyl-8-quinolinoxy)-3-pyridinesulfonamide Drug Info [530766]
4-(2-Phenylacetamido)-3-bromobenzenesulfonamide Drug Info [530219]
4-(2-Phenylacetamido)-3-chlorobenzenesulfonamide Drug Info [530219]
4-(2-Phenylacetamido)-3-fluorobenzenesulfonamide Drug Info [530219]
4-(2-Phenylacetamido)benzenesulfonamide Drug Info [530219]
4-(2-Phenylacetamidoethyl)benzenesulfonamide Drug Info [530219]
4-(2-Phenylacetamidomethyl)benzenesulfonamide Drug Info [530219]
4-(2-Propynylthio)pyridine-3-sulfonamide Drug Info [530766]
4-(2-Pyridin-2-ylacetamido)benzenesulfonamide Drug Info [530219]
4-(2-Pyridin-4-ylacetamido)benzenesulfonamide Drug Info [530219]
4-(4-Cyanophenoxy)-3-pyridinesulfonamide Drug Info [530766]
4-(4-Fluorophenoxy)-3-pyridinesulfonamide Drug Info [530766]
4-(4-hydroxy-benzylideneamino)-benzenesulfonamide Drug Info [530416]
4-(4-hydroxybenzylideneamino)benzoic acid Drug Info [530416]
4-(4-tert-butylbenzylideneamino)benzoic acid Drug Info [530416]
4-(5-Methyl-2-pirazolino)-3-pyridinesulfonamide Drug Info [530766]
4-(Allylamino)-3-pyridinesulfonamide Drug Info [530766]
4-(benzylideneamino)benzenesulfonamide Drug Info [530416]
4-(benzylideneamino)benzoic acid Drug Info [530416]
4-(Carbamolymethylthio)pyridine-3-sulfonamide Drug Info [530766]
4-(Cyanomethylthio)pyridine-3-sulfonamide Drug Info [530766]
4-(Hydroxymercury)Benzoic Acid Drug Info [551393]
4-(hydroxymethyl)benzenesulfonamide Drug Info [530466]
4-(Methylhydrazino)-3-pyridinesulfonamide Drug Info [530766]
4-(N-Methyl-hydrazino)-benzenesulfonamide Drug Info [527407]
4-(N-Oxide-2-pyridylthio)pyridine-3-sulfonamide Drug Info [530766]
4-(Quinolinoxy)-3-pyridinesulfonamide Drug Info [530766]
4-Amino-3-bromo-benzenesulfonamide Drug Info [530466]
4-Amino-3-chloro-benzenesulfonamide Drug Info [530466]
4-Amino-3-fluoro-benzenesulfonamide Drug Info [531031]
4-Amino-3-iodo-benzenesulfonamide Drug Info [530466]
4-amino-6-chlorobenzene-1,3-disulfonamide Drug Info [531031]
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide Drug Info [530466]
4-azidobenzenesulfonamide Drug Info [529609]
4-Benzenesulfonylamino-benzenesulfonamide Drug Info [527743]
4-Benzythiopyridine-3-sulfonamide Drug Info [530766]
4-bromophenylboronic acid Drug Info [530086]
4-butylphenylboronic acid Drug Info [530086]
4-Chloro-N-(5-sulfamoyl-indan-2-yl)-benzamide Drug Info [527262]
4-CYANOPHENOL Drug Info [529562]
4-Ethoxy-3-pyridinesulfonamide Drug Info [530766]
4-ethynyl benzene sulfonamide Drug Info [529344]
4-Flourobenzenesulfonamide Drug Info [551393]
4-fluoro-N-(4-sulfamoylbenzyl)benzenesulfonamide Drug Info [529884]
4-Hydrazino-3-pyridinesulfonamide Drug Info [530766]
4-Hydrazino-benzenesulfonamide Drug Info [529948]
4-Hydrazinocarbonyl-benzenesulfonamide Drug Info [527482]
4-isothiocyanatobenzenesulfonamide Drug Info [527233]
4-Methanesulfonylamino-benzenesulfonamide Drug Info [527743]
4-Methoxy-3-pyridinesulfonamide Drug Info [530766]
4-methoxyphenylboronic acid Drug Info [530086]
4-methoxyphenylsulfamide Drug Info [528233]
4-methyl-2-oxo-2H-chromen-7-yl sulfamate Drug Info [527782]
4-Methylamino-benzenesulfonamide Drug Info [527407]
4-Methylimidazole Drug Info [551391]
4-methylphenyl-difluoromethanesulfonamide Drug Info [527782]
4-Methylthiopyridine-3-sulfonamide Drug Info [530766]
4-Nitro-benzenesulfonamide Drug Info [527253]
4-nitrophenyl phosphate Drug Info [531156]
4-nitrophenyl-difluoromethanesulfonamide Drug Info [527782]
4-nitrophenylsulfamide Drug Info [528233]
4-phenoxyphenylboronic acid Drug Info [530086]
4-Sulfonamide-[1-(4-Aminobutane)]Benzamide Drug Info [551393]
4-Thiocyanato-benzenesulfonamide Drug Info [527253]
4-[2-(2-Thienyl)acetamidoethyl]benzenesulfonamide Drug Info [530219]
4-[2-(2-Thienyl)acetamido]benzenesulfonamide Drug Info [530219]
4-[2-(3-Phenyl-ureido)-ethyl]-benzenesulfonamide Drug Info [527743]
5-amino-1,3,4-thiadiazole-2-sulfonamide Drug Info [531112]
5-Amino-[1,3,4]thiadiazole-2-thiol Drug Info [527519]
5-Chlorosalicylic Acid Drug Info [529721]
5-hydroxy-1-tosyl-1H-pyrrol-2(5H)-one Drug Info [530979]
6-(aminomethyl)-2H-chromen-2-one Drug Info [530514]
6-(hydroxymethyl)-2H-chromen-2-one Drug Info [530514]
6-Amino-benzothiazole-2-sulfonic acid amide Drug Info [525539]
6-ethoxy-1,3-benzothiazole-2-sulfonamide Drug Info [551374]
6-Hydroxy-benzothiazole-2-sulfonic acid amide Drug Info [529948]
6-hydroxybenzo[d][1,3]oxathiol-2-one Drug Info [529555]
6-methoxy-2-oxo-2H-chromene-3-carboxylic acid Drug Info [530514]
6-methyl-2-oxo-2H-chromene-3-carboxylic acid Drug Info [530514]
6-Nitro-benzothiazole-2-sulfonic acid amide Drug Info [527253]
Acetate Ion Drug Info [551393]
AL4623 Drug Info [551393]
AL5300 Drug Info [551393]
AL5424 Drug Info [551393]
AL5927 Drug Info [551393]
AL6528 Drug Info [551393]
Al7089a Drug Info [551393]
AL7099A Drug Info [551391]
AL7182 Drug Info [551393]
Allyl 4-(aminosulfonyl)benzoate Drug Info [527786]
Aminobenzolamide derivative Drug Info [527261]
Azide Drug Info [527231]
BENZOLAMIDE Drug Info [530466]
Benzothiazole-2-sulfonic acid amide Drug Info [527408]
Benzthiazide Drug Info [535820], [535824]
Beta-Mercaptoethanol Drug Info [551393]
Beta-naphthylboronic acid Drug Info [530086]
Biphenyl-4-ylboronic acid Drug Info [530086]
Carzenide Drug Info [527786]
CATECHIN Drug Info [531068]
CATECHOL Drug Info [530751]
CG-100649 Drug Info [533275]
Chlorothiazide Drug Info [534975]
COUMARIN Drug Info [531259]
COUMATE Drug Info [529605]
Curcumin Drug Info [531068]
Cyclothiazide Drug Info [537999]
Dansylamide Drug Info [551393]
Decane-1,10-diyl disulfamate Drug Info [530359]
Decyl sulfamate Drug Info [530359]
Di(2,6-di-t-butylphenol) Drug Info [529973]
Di(2,6-diisopropylphenol) Drug Info [529973]
Di(2,6-dimethylphenol) Drug Info [529973]
Dorzolamide Drug Info [537461]
ELLAGIC ACID Drug Info [530751]
EMATE Drug Info [528582]
Ethinamate Drug Info [535861]
FERULIC ACID Drug Info [530751]
Formic Acid Drug Info [551393]
GALLICACID Drug Info [530751]
GUAIACOL Drug Info [529973]
HYDROSULFIDE Drug Info [527231]
Indane-5-sulfonamide Drug Info [551374]
IODIDE Drug Info [527231]
MAFENIDE Drug Info [530765]
Mercuribenzoic Acid Drug Info [551393]
Methyl 4-(4-hydroxybenzylideneamino)benzoate Drug Info [530416]
Methyl 4-(4-tert-butylbenzylideneamino)benzoate Drug Info [530416]
Methyl Mercury Ion Drug Info [551393]
Methyl-phosphonic acid Drug Info [527462]
MMI270 Drug Info [528653]
N-(1-benzofuran-3-ylmethyl)sulfamide Drug Info [530089]
N-(2,6-Diflouro-Benzyl)-4-Sulfamoyl-Benzamide Drug Info [551393]
N-(2-Flouro-Benzyl)-4-Sulfamoyl-Benzamide Drug Info [551393]
N-(2-Thienylmethyl)-2,5-Thiophenedisulfonamide Drug Info [551393]
N-(4-cyanophenyl)sulfamide Drug Info [527520]
N-(4-Sulfamoyl-phenyl)-benzamide Drug Info [527743]
N-(4-Sulfamoyl-phenyl)-butyramide Drug Info [527743]
N-(4-Sulfamoyl-phenyl)-isobutyramide Drug Info [527743]
N-(4-Sulfamoyl-phenyl)-propionamide Drug Info [527743]
N-(4-sulfamoylphenylethyl)-4-sulfamoylbenzamide Drug Info [551223]
N-(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamide Drug Info [529794]
N-(5-Mercapto-[1,3,4]thiadiazol-2-yl)-acetamide Drug Info [527519]
N-(5-phenyl-1,3,4-thiadiazol-2-yl)sulfamide Drug Info [529794]
N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)sulfamide Drug Info [529794]
N-(pentafluorophenyl)sulfamide Drug Info [527520]
N-1,3,4-thiadiazol-2-ylsulfamide Drug Info [529794]
N-Benzyl-4-Sulfamoyl-Benzamide Drug Info [551393]
N-hydroxysulfamide Drug Info [530922]
N-hydroxysulfonamides Drug Info [538135]
N-propynyl amidebenzenesulphonide Drug Info [528491]
N-unsubstituted carbamate esters Drug Info [535861]
N-[(4-bromo-1-benzothien-3-yl)methyl]sulfamide Drug Info [530089]
N-[(5-chloro-1-benzothien-3-yl)methyl]sulfamide Drug Info [530089]
N-[2-(1h-Indol-5-Yl)-Butyl]-4-Sulfamoyl-Benzamide Drug Info [551393]
N-[4-(trifluoromethyl)phenyl]sulfamide Drug Info [527520]
N-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]sulfamide Drug Info [529794]
N-[5-(methylthio)-1,3,4-thiadiazol-2-yl]sulfamide Drug Info [529794]
NITRATE Drug Info [527231]
NSC-654077 Drug Info [529381]
Octane-1,8-diyl disulfamate Drug Info [530359]
Octyl sulfamate Drug Info [530359]
P-Coumaric Acid Drug Info [530751]
P-tolylboronic acid Drug Info [530086]
PARABEN Drug Info [530751]
PARAOXON Drug Info [531156]
Pentane-1,5-diamine Drug Info [530998]
Pentanoic acid (4-sulfamoyl-phenyl)-amide Drug Info [527743]
Phenethylboronic acid Drug Info [530086]
PHENOL Drug Info [531068]
Phenoxyarsonous acid Drug Info [527231]
Phenyl Boronic acid Drug Info [527231]
Phenyl-phosphonic acid Drug Info [527462]
PHENYLSULFAMATE Drug Info [528233]
PHENYLSULFAMIDE Drug Info [528233]
PRONTOCIL Drug Info [530292]
Prop-2-ynyl 4-sulfamoylbenzoate Drug Info [528491]
Quinoline-8-sulfonamide Drug Info [529884]
RESORCINOL Drug Info [529562]
SACCHARIN Drug Info [531031]
SALICYLATE Drug Info [529562]
Sodium 2,3,5,6-tetrafluorobenzoate Drug Info [530027]
Sodium trithiocarbonate Drug Info [530003]
SPARFOSIC ACID Drug Info [527462]
SULFAMATE Drug Info [527231]
Sulfamic acid 12-sulfamoyloxy-dodecyl ester Drug Info [527391]
Sulfamic acid 16-sulfamoyloxy-hexadecyl ester Drug Info [527391]
Sulfamic acid 3-sulfamoyloxy-phenyl ester Drug Info [527391]
Sulfamic acid 4-sulfamoyloxy-butyl ester Drug Info [527391]
Sulfamic acid 4-sulfamoyloxymethyl-benzyl ester Drug Info [527391]
Sulfamic acid 6-sulfamoyloxy-hexyl ester Drug Info [527391]
Sulfamic acid 7-sulfamoyloxy-heptyl ester Drug Info [527391]
Sulfamic acid benzo[1,3]dioxol-2-ylmethyl ester Drug Info [527479]
Sulfamic acid chroman-2-ylmethyl ester Drug Info [527479]
SULFAMIDE Drug Info [527231]
Sulfanilamide derivative Drug Info [527560]
Sulfenamido-sulfonamides Drug Info [538055]
SULTHIAME Drug Info [551374]
Syringic Acid Drug Info [530751]
Thioureido sulfonamide Drug Info [527655]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
KEGG Pathway Nitrogen metabolism
Proximal tubule bicarbonate reclamation
Collecting duct acid secretion
Gastric acid secretion
Pancreatic secretion
Bile secretion
NetPath Pathway IL4 Signaling Pathway
EGFR1 Signaling Pathway
Reactome Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxide
WikiPathways Reversible Hydration of Carbon Dioxide
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
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Ref 538347FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 083206.
Ref 538352FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 084026.
Ref 538422FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 009750.
Ref 538463FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 013157.
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Ref 525539J Med Chem. 1999 Jul 15;42(14):2641-50.Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?.
Ref 527231Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9.Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.
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