| Drug General Information |
| Drug ID |
D0VD0C
|
| Former ID |
DNC004886
|
| Drug Name |
MAFENIDE
|
| Drug Type |
Small molecular drug
|
| Indication |
Bacterial infection [ICD10:A00-B99]
|
Approved |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C7H10N2O2S
|
| Canonical SMILES |
C1=CC(=CC=C1CN)S(=O)(=O)N
|
| InChI |
1S/C7H10N2O2S/c8-5-6-1-3-7(4-2-6)12(9,10)11/h1-4H,5,8H2,(H2,9,10,11)
|
| InChIKey |
TYMRLRRVMHJFTF-UHFFFAOYSA-N
|
| CAS Number |
CAS 138-39-6
|
| PubChem Compound ID |
|
| SuperDrug ATC ID |
D06BA03
|
| Target and Pathway |
| Target(s) |
Carbonic anhydrase II |
Target Info |
Inhibitor |
[1]
|
|---|
| Carbonic anhydrase XII |
Target Info |
Inhibitor |
[1]
|
| Carbonic anhydrase VI |
Target Info |
Inhibitor |
[2]
|
| Carbonic anhydrase IX |
Target Info |
Inhibitor |
[1]
|
| Carbonic anhydrase XIV |
Target Info |
Inhibitor |
[3]
|
| Carbonic anhydrase IV |
Target Info |
Inhibitor |
[4]
|
| Carbonic anhydrase |
Target Info |
Inhibitor |
[2]
|
|
KEGG Pathway
|
Nitrogen metabolism
|
|
Proximal tubule bicarbonate reclamation
|
|
Collecting duct acid secretion
|
|
Gastric acid secretion
|
|
Pancreatic secretion
|
|
Bile secretionhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
|
|
NetPath Pathway
|
IL4 Signaling Pathway
|
|
EGFR1 Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
|
|
Pathway Interaction Database
|
HIF-1-alpha transcription factor network
|
|
Reactome
|
Erythrocytes take up carbon dioxide and release oxygen
|
|
Erythrocytes take up oxygen and release carbon dioxide
|
|
Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor
|
|
Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
|
|
Reversible hydration of carbon dioxide
|
|
WikiPathways
|
Reversible Hydration of Carbon Dioxide
|
|
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
|
|
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide
|
|
miR-targeted genes in muscle cell - TarBase
|
|
miR-targeted genes in leukocytes - TarBase
|
|
miR-targeted genes in epithelium - TarBaseWP2770:Reversible Hydration of Carbon DioxideWP2877:Vitamin D Receptor Pathway
|
|
Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon DioxideWP2770:Reversible Hydration of Carbon Dioxide
|
|
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
|
| References |
| REF 1 | J Med Chem. 2010 Apr 8;53(7):2913-26.Sulfonamide linked neoglycoconjugates--a new class of inhibitors for cancer-associated carbonic anhydrases. |
|---|
| REF 2 | J Med Chem. 2009 Feb 12;52(3):646-54.Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. |
|---|
| REF 3 | Bioorg Med Chem Lett. 2005 Sep 1;15(17):3828-33.Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides. |
|---|
| REF 4 | Bioorg Med Chem Lett. 2005 Feb 15;15(4):1149-54.Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides. |
|---|
