| Drug General Information |
| Drug ID |
D0F7SO
|
| Former ID |
DNC009044
|
| Drug Name |
Quinoline-8-sulfonamide
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C9H8N2O2S
|
| Canonical SMILES |
C1=CC2=C(C(=C1)S(=O)(=O)N)N=CC=C2
|
| InChI |
1S/C9H8N2O2S/c10-14(12,13)8-5-1-3-7-4-2-6-11-9(7)8/h1-6H,(H2,10,12,13)
|
| InChIKey |
ZTYZEUXZHGOXRT-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Carbonic anhydrase IX |
Target Info |
Inhibitor |
[1]
|
|---|
| Carbonic anhydrase II |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Nitrogen metabolismhsa00910:Nitrogen metabolism
|
|
Proximal tubule bicarbonate reclamation
|
|
Collecting duct acid secretion
|
|
Gastric acid secretion
|
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Pancreatic secretion
|
|
Bile secretion
|
|
NetPath Pathway
|
IL4 Signaling Pathway
|
|
EGFR1 Signaling Pathway
|
|
Pathway Interaction Database
|
HIF-1-alpha transcription factor network
|
|
Reactome
|
Regulation of gene expression by Hypoxia-inducible Factor
|
|
Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
|
|
Erythrocytes take up oxygen and release carbon dioxide
|
|
Reversible hydration of carbon dioxide
|
|
WikiPathways
|
Vitamin D Receptor Pathway
|
|
Reversible Hydration of Carbon Dioxide
|
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Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon Dioxide
|
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Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
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|
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
|
| References |
| REF 1 | Bioorg Med Chem. 2009 Jan 15;17(2):553-7. Epub 2008 Dec 6.Ligand-based and structure-based virtual screening to identify carbonic anhydrase IX inhibitors. |
|---|
