Drug General Information
Drug ID	D04APY
Former ID	DIB008912
Drug Name	KC-11404
Indication	Asthma [ICD10:J45]		Terminated	[533776]
Company	Solvay Deutschland GmbH
Structure		Download 2D MOL 3D MOL
Canonical SMILES	n12c(c(c3c1c(cc(c3)O)CCC2CCCC)CCN1CCN(c2nccc(c2)C)CC1)C
CAS Number	CAS 148490-22-6
Target and Pathway
Target(s)	Arachidonate 5-lipoxygenase	Target Info	Modulator	[533776]
	Platelet-activating factor receptor	Target Info	Modulator	[533776]
BioCyc Pathway	Aspirin-triggered lipoxin biosynthesis
	Resolvin D biosynthesis
	Leukotriene biosynthesis
	Lipoxin biosynthesis
	Aspirin triggered resolvin D biosynthesis
	Aspirin triggered resolvin E biosynthesis
KEGG Pathway	Arachidonic acid metabolism
	Metabolic pathways
	Serotonergic synapse
	Ovarian steroidogenesis
	Toxoplasmosishsa04020:Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Staphylococcus aureus infection
NetPath Pathway	IL4 Signaling PathwayNetPath_17:IL5 Signaling Pathway
	Leptin Signaling Pathway
PathWhiz Pathway	Arachidonic Acid Metabolism
Reactome	Class A/1 (Rhodopsin-like receptors)
	G alpha (q) signalling events
	Interferon gamma signaling
WikiPathways	Vitamin D Receptor Pathway
	Arachidonic acid metabolism
	Eicosanoid Synthesis
	Selenium Micronutrient NetworkWP455:GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Small Ligand GPCRs
	Interferon gamma signaling
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 533776	Synthesis, structure-activity relationships, and pharmacological evaluation of pyrrolo[3,2,1-ij]quinoline derivatives: potent histamine and platelet activating factor antagonism and 5-lipoxygenase inhibitory properties. Potential therapeutic application in asthma. J Med Chem. 1995 Feb 17;38(4):669-85.
Ref 533776	Synthesis, structure-activity relationships, and pharmacological evaluation of pyrrolo[3,2,1-ij]quinoline derivatives: potent histamine and platelet activating factor antagonism and 5-lipoxygenase inhibitory properties. Potential therapeutic application in asthma. J Med Chem. 1995 Feb 17;38(4):669-85.

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