Drug Information

Drug General Information
Drug ID
D04JTD
Former ID
DCL000205
Drug Name
PX-12
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Phase 2 [528013]
Therapeutic Class
Anticancer Agents
Company
Biomira
Structure
Download
2D MOL

3D MOL
Formula
C7H12N2S2
Canonical SMILES
CCC(C)SSC1=NC=CN1
InChIKey
BPBPYQWMFCTCNG-UHFFFAOYSA-N
CAS Number
CAS 141400-58-0
PubChem Compound ID
219104
PubChem Substance ID
9374284, 15219811, 30422463, 57399846, 79245557, 103106749, 103564705, 113468605, 117402020, 123121574, 126460084, 135142363, 140114675, 162249061, 162310065, 162790932, 164154946, 164210775, 170364272, 174006855, 175427007, 177748841, 204361145, 210274949, 210280587, 215774935, 223392225, 223435396, 227058245, 243264143, 252156900, 252161718, 252475622
Target and Pathway
Target(s) Thioredoxin Target Info Inhibitor [536388], [536492], [536593]
NetPath Pathway IL2 Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Hypoxia response via HIF activation
Oxidative stress response
Pathway Interaction Database p38 MAPK signaling pathway
Signaling events mediated by PTP1B
TNF receptor signaling pathway
PathWhiz Pathway Purine Metabolism
Reactome Oxidative Stress Induced Senescence
Detoxification of Reactive Oxygen Species
TP53 Regulates Metabolic Genes
The NLRP3 inflammasome
WikiPathways NRF2 pathway
Nuclear Receptors Meta-Pathway
Detoxification of Reactive Oxygen Species
Human Complement System
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
TNF alpha Signaling Pathway
Metabolism of nucleotides
Selenium Micronutrient Network
References
Ref 528013The antitumor thioredoxin-1 inhibitor PX-12 (1-methylpropyl 2-imidazolyl disulfide) decreases thioredoxin-1 and VEGF levels in cancer patient plasma. J Lab Clin Med. 2006 Feb;147(2):83-90.
Ref 536388A Phase I pharmacokinetic and pharmacodynamic study of PX-12, a novel inhibitor of thioredoxin-1, in patients with advanced solid tumors. Clin Cancer Res. 2007 Apr 1;13(7):2109-14.
Ref 536492Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2007 Jun;29(5):359-73.
Ref 5365932-[(1-methylpropyl)dithio]-1H-imidazole inhibits tubulin polymerization through cysteine oxidation. Mol Cancer Ther. 2008 Jan;7(1):143-51.

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