Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D04JTY
|
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| Former ID |
DNC001434
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| Drug Name |
Thiolactomycin
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| Drug Type |
Small molecular drug
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| Indication | Urinary tract and intraperitoneal bacterial infection [ICD10:N39.0] | Investigative | [1572605] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C11H14O2S
|
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| Canonical SMILES |
CC1=C(SC(C1=O)(C)C=C(C)C=C)O
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| InChI |
1S/C11H14O2S/c1-5-7(2)6-11(4)9(12)8(3)10(13)14-11/h5-6,13H,1H2,2-4H3/b7-6+/t11-/m1/s1
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| InChIKey |
HGCGJTZCWZFGBT-XUIVZRPNSA-N
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| CAS Number |
CAS 82079-32-1
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| PubChem Compound ID | |||||
| PubChem Substance ID |
13347, 621341, 819775, 7890788, 12015257, 16288707, 17405466, 24278631, 32964498, 36888281, 46391893, 46491024, 46505720, 48169378, 50054156, 50106765, 50106766, 52110779, 53778014, 53813060, 57391946, 57404693, 84975004, 92304107, 103551068, 104065270, 104634710, 121361562, 124750089, 134338703, 134339547, 134340616, 135030651, 137245183, 140421192, 160967345, 163564862, 164187185, 179678465, 184534105, 208013918, 237212483, 238329620, 241163324
|
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| Drug Resistance Mutation (DRM) | |||||
| DRM | DRM Info | ||||
| Target and Pathway | |||||
| Target(s) | Enoyl-ACP reductase | Target Info | Inhibitor | [536636] | |
| Beta-ketoacyl-ACP synthase III | Target Info | Binder | [535329] | ||
| 3-oxoacyl-[acyl-carrier-protein] synthase II | Target Info | Binder | [531635] | ||
| Beta-ketoacyl-ACP synthase I | Target Info | Binder | [531635] | ||
| References | |||||
| Ref 531635 | Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36. | ||||
| Ref 535329 | The apicoplast as an antimalarial drug target. Drug Resist Updat. 2001 Jun;4(3):145-51. | ||||
| Ref 536636 | Novel molecular targets for antimalarial drug development. Chem Biol Drug Des. 2008 Apr;71(4):287-97. Epub 2008 Feb 22. | ||||
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