Drug General Information
Drug ID	D04MYT
Former ID	DNC010678
Drug Name	4-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530806]
Structure		Download 2D MOL 3D MOL
Formula	C10H8N4
Canonical SMILES	C1=CNC2=NC=CC(=C21)C3=CNN=C3
InChI	1S/C10H8N4/c1-3-11-10-9(2-4-12-10)8(1)7-5-13-14-6-7/h1-6H,(H,11,12)(H,13,14)
InChIKey	FATFDRYYCYZBQB-UHFFFAOYSA-N
PubChem Compound ID	46885627
Target and Pathway
Target(s)	mRNA of Aurora B	Target Info	Inhibitor	[530806]
	Aurora kinase A	Target Info	Inhibitor	[530806]
KEGG Pathway	Oocyte meiosis
Pathway Interaction Database	Aurora B signaling
	Signaling by Aurora kinases
	Aurora C signaling
	FOXM1 transcription factor network
	Aurora A signalingaurora_b_pathway:Aurora B signaling
	Integrin-linked kinase signaling
	PLK1 signaling events
	Aurora A signaling
Reactome	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
	Separation of Sister Chromatids
	Resolution of Sister Chromatid Cohesion
	RHO GTPases Activate Formins
	Mitotic PrometaphaseR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
	Regulation of PLK1 Activity at G2/M Transition
WikiPathways	Mitotic Metaphase and Anaphase
	Mitotic Prometaphase
	Regulation of Microtubule Cytoskeleton
	miR-targeted genes in lymphocytes - TarBase
	miR-targeted genes in epithelium - TarBase
	APC/C-mediated degradation of cell cycle proteinsWP437:EGF/EGFR Signaling Pathway
	JAK/STAT
	Gastric Cancer Network 1
	Integrated Breast Cancer Pathway
	APC/C-mediated degradation of cell cycle proteins
References
Ref 530806	Bioorg Med Chem Lett. 2010 Apr 15;20(8):2552-5. Epub 2010 Mar 1.Discovery of a new series of Aurora inhibitors through truncation of GSK1070916.
Ref 530806	Bioorg Med Chem Lett. 2010 Apr 15;20(8):2552-5. Epub 2010 Mar 1.Discovery of a new series of Aurora inhibitors through truncation of GSK1070916.

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