Target Information
Target General Infomation | |||||
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Target ID |
T77764
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Former ID |
TTDR01420
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Target Name |
mRNA of Aurora B
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Gene Name |
AURKB
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Synonyms |
AIM1 (mRNA); ARK2 (mRNA); Aurora 1 (mRNA); Aurora and IPL1like midbodyassociated protein 1 (mRNA); Aurora kinase B (mRNA); Aurora/IPL1related kinase 2 (mRNA); Aurorarelated kinase 2 (mRNA); STK1 (mRNA); Serine/threonineprotein kinase 12 (mRNA); Serine/threonineprotein kinase 5 (mRNA); Serine/threonineprotein kinase auroraB (mRNA); AURKB
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Target Type |
Clinical Trial
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Disease | Prostate cancer [ICD9: 185; ICD10: C61] | ||||
BioChemical Class |
Kinase
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Target Validation |
T77764
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UniProt ID | |||||
EC Number |
EC 2.7.11.1
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Sequence |
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA |
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Drugs and Mode of Action | |||||
Inhibitor | 4-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine | Drug Info | [530806] | ||
4-(4'-Benzamidoanilino)-6,7-dimethoxyquinazoline | Drug Info | [529213] | |||
6-bromoindirubin-3-oxime | Drug Info | [528968] | |||
7-bromoindirubin-3-oxime | Drug Info | [528968] | |||
7-chloroindirubin-3-oxime | Drug Info | [528968] | |||
7-fluoroindirubin-3-acetoxime | Drug Info | [528968] | |||
7-fluoroindirubin-3-oxime | Drug Info | [528968] | |||
7-iodoindirubin-3-oxime | Drug Info | [528968] | |||
CGP-57380 | Drug Info | [529039] | |||
compound 1 | Drug Info | [532161] | |||
compound 10 | Drug Info | [530097] | |||
compound 25 | Drug Info | [531168] | |||
compound 46 | Drug Info | [528000] | |||
HESPERADIN | Drug Info | [528000] | |||
Indirubin-3-acetoxime | Drug Info | [528968] | |||
Indirubin-3-methoxime | Drug Info | [528968] | |||
Indirubin-3-oxime | Drug Info | [528968] | |||
PHA-739358 | Drug Info | [527513] | |||
quinazoline deriv. 1 | Drug Info | [529213] | |||
SU 6656 | Drug Info | [529039] | |||
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
Pathway Interaction Database | Aurora B signaling | ||||
Signaling by Aurora kinases | |||||
Aurora C signaling | |||||
FOXM1 transcription factor network | |||||
Aurora A signaling | |||||
Reactome | Cdh1 targeted proteins in late mitosis/early G1 | ||||
Separation of Sister Chromatids | |||||
Resolution of Sister Chromatid Cohesion | |||||
RHO GTPases Activate Formins | |||||
Mitotic Prometaphase | |||||
WikiPathways | Mitotic Metaphase and Anaphase | ||||
Mitotic Prometaphase | |||||
Regulation of Microtubule Cytoskeleton | |||||
miR-targeted genes in lymphocytes - TarBase | |||||
miR-targeted genes in epithelium - TarBase | |||||
APC/C-mediated degradation of cell cycle proteins | |||||
References | |||||
Ref 527513 | J Med Chem. 2005 Apr 21;48(8):3080-4.Potent and selective Aurora inhibitors identified by the expansion of a novel scaffold for protein kinase inhibition. | ||||
Ref 528000 | J Med Chem. 2006 Feb 9;49(3):955-70.Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B kinase inhibitors. | ||||
Ref 528968 | J Med Chem. 2007 Aug 23;50(17):4027-37. Epub 2007 Aug 1.An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins. | ||||
Ref 529039 | Biochem J. 2007 Dec 15;408(3):297-315.The selectivity of protein kinase inhibitors: a further update. | ||||
Ref 529213 | Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. Epub 2007 Dec 11.A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. | ||||
Ref 530097 | A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B. J Med Chem. 2009 May 28;52(10):3300-7. | ||||
Ref 530806 | Bioorg Med Chem Lett. 2010 Apr 15;20(8):2552-5. Epub 2010 Mar 1.Discovery of a new series of Aurora inhibitors through truncation of GSK1070916. | ||||
Ref 531168 | Discovery of orally bioavailable imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6739-43. |
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