| Drug General Information |
| Drug ID |
D0CE3R
|
| Former ID |
DNC009914
|
| Drug Name |
SU 6656
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C19H21N3O3S
|
| InChI |
InChI=1S/C19H21N3O3S/c1-22(2)26(24,25)14-7-8-18-15(11-14)16(19(23)21-18)10-13-9-12-5-3-4-6-17(12)20-13/h7-11,20H,3-6H2,1-2H3,(H,21,23)/b16-10-
|
| InChIKey |
LOGJQOUIVKBFGH-YBEGLDIGSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
7980430, 11056898, 11111835, 14877437, 17405537, 24278818, 26759570, 26759571, 39341756, 47736279, 47885230, 50106863, 50106864, 53778085, 53790164, 56463485, 57359522, 78377442, 85231238, 85787153, 90341374, 91722389, 92303186, 99302734, 99444510, 103722995, 104161488, 114157969, 121361823, 121379920, 124750143, 124800034, 124881505, 124881506, 124881507, 134347531, 135697724, 139657756, 152133990, 160969094, 163564933, 163687284, 163687285, 178102666, 179235838, 187071970, 204359714, 242275770, 251920428, 252159891
|
| Target and Pathway |
| Target(s) |
Aurora protein kinase |
Target Info |
Inhibitor |
[2]
|
|---|
| Proto-oncogene tyrosine-protein kinase SRC |
Target Info |
Inhibitor |
[2]
|
| Lck tyrosine kinase |
Target Info |
Inhibitor |
[2]
|
| AMP-activated protein kinase |
Target Info |
Inhibitor |
[2]
|
| mRNA of Aurora B |
Target Info |
Inhibitor |
[2]
|
|
KEGG Pathway
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Oocyte meiosishsa04012:ErbB signaling pathway
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Rap1 signaling pathway
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Chemokine signaling pathway
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Endocytosis
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VEGF signaling pathway
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Focal adhesion
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Adherens junction
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Tight junction
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Gap junction
|
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Platelet activation
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GABAergic synapse
|
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Inflammatory mediator regulation of TRP channels
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Regulation of actin cytoskeleton
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GnRH signaling pathway
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Estrogen signaling pathway
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Prolactin signaling pathway
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Thyroid hormone signaling pathway
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Oxytocin signaling pathway
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Bacterial invasion of epithelial cells
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Epithelial cell signaling in Helicobacter pylori infection
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Shigellosis
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Tuberculosis
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Hepatitis B
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Viral carcinogenesis
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Proteoglycans in cancerhsa04064:NF-kappa B signaling pathway
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Osteoclast differentiation
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Natural killer cell mediated cytotoxicity
|
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T cell receptor signaling pathway
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HTLV-I infection
|
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Primary immunodeficiencyhsa04068:FoxO signaling pathway
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Regulation of autophagy
|
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mTOR signaling pathway
|
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PI3K-Akt signaling pathway
|
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AMPK signaling pathway
|
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Circadian rhythm
|
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Insulin signaling pathway
|
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Adipocytokine signaling pathway
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Glucagon signaling pathway
|
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Non-alcoholic fatty liver disease (NAFLD)
|
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Hypertrophic cardiomyopathy (HCM)
|
|
NetPath Pathway
|
IL2 Signaling PathwayNetPath_11:TCR Signaling Pathway
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IL2 Signaling Pathway
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PANTHER Pathway
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Angiogenesis
|
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Cadherin signaling pathway
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Integrin signalling pathway
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Parkinson disease
|
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CCKR signaling map STP00049:Parkinson disease
|
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T cell activation
|
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Pathway Interaction Database
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Endothelins
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Signaling events mediated by PRL
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LPA receptor mediated events
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Atypical NF-kappaB pathway
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Glypican 1 network
|
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Plasma membrane estrogen receptor signaling
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Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
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Signaling events mediated by PTP1B
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S1P3 pathway
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EPHB forward signaling
|
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Nectin adhesion pathway
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Regulation of p38-alpha and p38-beta
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CDC42 signaling events
|
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Signaling events regulated by Ret tyrosine kinase
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Arf6 signaling events
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Signaling events mediated by TCPTP
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FAS (CD95) signaling pathway
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Thromboxane A2 receptor signaling
|
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Netrin-mediated signaling events
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Alpha9 beta1 integrin signaling events
|
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CXCR4-mediated signaling events
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EGF receptor (ErbB1) signaling pathway
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Class I PI3K signaling events
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Posttranslational regulation of adherens junction stability and dissassembly
|
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Regulation of Androgen receptor activity
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E-cadherin signaling in the nascent adherens junction
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amb2 Integrin signaling
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Integrins in angiogenesis
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ErbB1 downstream signaling
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Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
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ErbB2/ErbB3 signaling events
|
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EPHA forward signaling
|
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E-cadherin signaling in keratinocytes
|
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PDGFR-beta signaling pathway
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Nongenotropic Androgen signaling
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Internalization of ErbB1
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CXCR3-mediated signaling events
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Signaling events mediated by VEGFR1 and VEGFR2
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Syndecan-2-mediated signaling events
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Class I PI3K signaling events mediated by Akt
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Syndecan-3-mediated signaling events
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Ephrin B reverse signaling
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Trk receptor signaling mediated by PI3K and PLC-gamma
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EPHA2 forward signaling
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Alpha-synuclein signaling
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FGF signaling pathway
|
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Alpha4 beta1 integrin signaling events
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Signaling events mediated by focal adhesion kinasenfkappabatypicalpathway:Atypical NF-kappaB pathway
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TCR signaling in naï
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IL12-mediated signaling events
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TCR signaling in naï
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SHP2 signaling
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IL2-mediated signaling events
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IL2 signaling events mediated by PI3K
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IL2 signaling events mediated by STAT5
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Alpha-synuclein signalingaurora_b_pathway:Aurora B signaling
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Signaling by Aurora kinases
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Aurora C signaling
|
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FOXM1 transcription factor network
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Aurora A signaling
|
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Reactome
|
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
|
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Separation of Sister Chromatids
|
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Resolution of Sister Chromatid Cohesion
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RHO GTPases Activate ForminsR-HSA-114604:GPVI-mediated activation cascade
|
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PIP3 activates AKT signaling
|
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Regulation of KIT signaling
|
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Phosphorylation of CD3 and TCR zeta chains
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Translocation of ZAP-70 to Immunological synapse
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Generation of second messenger molecules
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PECAM1 interactions
|
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Constitutive Signaling by Aberrant PI3K in Cancer
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DAP12 signaling
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CD28 co-stimulation
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CD28 dependent PI3K/Akt signaling
|
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CD28 dependent Vav1 pathway
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CTLA4 inhibitory signaling
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PD-1 signaling
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Interleukin-2 signalingR-HSA-1445148:Translocation of GLUT4 to the plasma membrane
|
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Macroautophagy
|
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Activation of PPARGC1A (PGC-1alpha) by phosphorylation
|
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TP53 Regulates Metabolic GenesR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
|
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RHO GTPases Activate Formins
|
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Mitotic Prometaphase
|
|
WikiPathways
|
EGF/EGFR Signaling Pathway
|
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JAK/STAT
|
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Gastric Cancer Network 1
|
|
Integrated Breast Cancer Pathway
|
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APC/C-mediated degradation of cell cycle proteinsWP673:ErbB Signaling Pathway
|
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Senescence and Autophagy in Cancer
|
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Notch Signaling Pathway
|
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EPO Receptor Signaling
|
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TGF beta Signaling Pathway
|
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Signaling of Hepatocyte Growth Factor Receptor
|
|
Kit receptor signaling pathway
|
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Pregnane X Receptor pathway
|
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Aryl Hydrocarbon Receptor Pathway
|
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IL-3 Signaling Pathway
|
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Nanoparticle-mediated activation of receptor signaling
|
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Polycystic Kidney Disease Pathway
|
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Alpha 6 Beta 4 signaling pathway
|
|
BDNF signaling pathway
|
|
Integrated Pancreatic Cancer Pathway
|
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Oncostatin M Signaling Pathway
|
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Interleukin-11 Signaling Pathway
|
|
AGE/RAGE pathway
|
|
Signaling Pathways in Glioblastoma
|
|
TSLP Signaling Pathway
|
|
Arylhydrocarbon receptor (AhR) signaling pathway
|
|
Regulation of Microtubule Cytoskeleton
|
|
FSH signaling pathway
|
|
Leptin signaling pathway
|
|
RANKL/RANK Signaling Pathway
|
|
Integrin-mediated Cell Adhesion
|
|
Angiogenesis
|
|
Androgen receptor signaling pathwayWP61:Notch Signaling Pathway
|
|
Interferon type I signaling pathways
|
|
IL-2 Signaling Pathway
|
|
Inflammatory Response Pathway
|
|
Signaling by SCF-KIT
|
|
DAP12 interactions
|
|
Host Interactions of HIV factors
|
|
PIP3 activates AKT signaling
|
|
T-Cell Receptor and Co-stimulatory Signaling
|
|
B Cell Receptor Signaling Pathway
|
|
TCR signaling
|
|
Costimulation by the CD28 familyWP481:Insulin Signaling
|
|
Energy dependent regulation of mTOR by LKB1-AMPK
|
|
SREBF and miR33 in cholesterol and lipid homeostasis
|
|
SREBP signalling
|
|
Signaling by Insulin receptor
|
|
TOR Signaling
|
|
AMPK SignalingWP2757:Mitotic Metaphase and Anaphase
|
|
Mitotic Prometaphase
|
|
miR-targeted genes in lymphocytes - TarBase
|
|
miR-targeted genes in epithelium - TarBase
|
|
APC/C-mediated degradation of cell cycle proteins
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6044). |
|---|
| REF 2 | Biochem J. 2007 Dec 15;408(3):297-315.The selectivity of protein kinase inhibitors: a further update. |
|---|
