Drug Information

Drug General Information
Drug ID
D04TPU
Former ID
DIB014744
Drug Name
RO-5323441
Synonyms
Placental growth factor inhibitors (humanized mAb, cancer), BioInvent/Thrombogenics/Roche; 89Zr-RO-5323441
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 2 [523948]
Company
F Hoffmann-La Roche Ltd
Target and Pathway
Target(s) Placenta growth factor Target Info Inhibitor [549755]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
PI3K-Akt signaling pathway
Focal adhesion
Pathways in cancer
NetPath Pathway TSH Signaling Pathway
Pathway Interaction Database VEGFR1 specific signals
Reactome VEGF ligand-receptor interactions
VEGF binds to VEGFR leading to receptor dimerization
WikiPathways Focal Adhesion
Signaling by VEGF
References
Ref 523948ClinicalTrials.gov (NCT01622764) 89Zr-RO5323441 PET Imaging in Glioblastoma. U.S. National Institutes of Health.
Ref 549755RO5323441, a humanized monoclonal antibody against the placenta growth factor, blocks PlGF-induced VEGFR-1 phosphorylation in vitro and tumor growth in vivo. Cancer Research. 01/2011.

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