Drug General Information
Drug ID	D04XNH
Former ID	DNC003659
Drug Name	Propionic acid 8-aza-bicyclo[3.2.1]oct-6-yl ester
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[525826]
Structure		Download 2D MOL 3D MOL
Formula	C10H17NO2
Canonical SMILES	CCC(=O)OC1CC2CCCC1N2
InChI	1S/C10H17NO2/c1-2-10(12)13-9-6-7-4-3-5-8(9)11-7/h7-9,11H,2-6H2,1H3
InChIKey	GSTSHGWHXRRCHO-UHFFFAOYSA-N
PubChem Compound ID	44318851
Target and Pathway
Target(s)	Muscarinic acetylcholine receptor M4	Target Info	Inhibitor	[525826]
	Muscarinic acetylcholine receptor M3	Target Info	Inhibitor	[525826]
	Muscarinic acetylcholine receptor M1	Target Info	Inhibitor	[525826]
	Muscarinic acetylcholine receptor M2	Target Info	Inhibitor	[525826]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Cholinergic synapse
	Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
	Regulation of actin cytoskeleton
	Insulin secretion
	Salivary secretion
	Gastric acid secretion
	Pancreatic secretionhsa04020:Calcium signaling pathway
	cAMP signaling pathway
	PI3K-Akt signaling pathway
PANTHER Pathway	Alzheimer disease-amyloid secretase pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Muscarinic acetylcholine receptor 2 and 4 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
	Muscarinic acetylcholine receptor 2 and 4 signaling pathway
PathWhiz Pathway	Gastric Acid ProductionPW000564:Muscle/Heart Contraction
Reactome	Muscarinic acetylcholine receptors
	G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
	Acetylcholine regulates insulin secretion
	G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
	G alpha (i) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	Regulation of Actin Cytoskeleton
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signalingWP58:Monoamine GPCRs
	Gastrin-CREB signalling pathway via PKC and MAPK
	Integration of energy metabolism
	GPCR downstream signaling
	GPCRs, OtherWP58:Monoamine GPCRs
	Secretion of Hydrochloric Acid in Parietal Cells
	GPCR downstream signalingWP706:SIDS Susceptibility Pathways
	GPCRs, Other
References
Ref 525826	J Med Chem. 2000 Jun 29;43(13):2514-22.6beta-Acyloxy(nor)tropanes: affinities for antagonist/agonist binding sites on transfected and native muscarinic receptors.
Ref 525826	J Med Chem. 2000 Jun 29;43(13):2514-22.6beta-Acyloxy(nor)tropanes: affinities for antagonist/agonist binding sites on transfected and native muscarinic receptors.

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