Drug Information

Drug General Information
Drug ID
D05EML
Former ID
DNC011500
Drug Name
1'-Benzyl-3-phenyl-[3,4']bipiperidinyl-2,6-dione
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533345]
Structure
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2D MOL

3D MOL
Formula
C23H26N2O2
Canonical SMILES
C1CN(CCC1C2(CCC(=O)NC2=O)C3=CC=CC=C3)CC4=CC=CC=C4
InChI
1S/C23H26N2O2/c26-21-11-14-23(22(27)24-21,19-9-5-2-6-10-19)20-12-15-25(16-13-20)17-18-7-3-1-4-8-18/h1-10,20H,11-17H2,(H,24,26,27)
InChIKey
LQQIVYSCPWCSSD-UHFFFAOYSA-N
PubChem Compound ID
21847
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M3 Target Info Inhibitor [533345]
Muscarinic acetylcholine receptor M2 Target Info Inhibitor [533345]
Muscarinic acetylcholine receptor M1 Target Info Inhibitor [533345]
Muscarinic acetylcholine receptor M5 Target Info Inhibitor [533345]
Muscarinic acetylcholine receptor M4 Target Info Inhibitor [533345]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeleton
Insulin secretion
Salivary secretion
Gastric acid secretion
Pancreatic secretionhsa04020:Calcium signaling pathway
cAMP signaling pathway
PI3K-Akt signaling pathway
Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
Regulation of actin cytoskeletonhsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathwayP00003:Alzheimer disease-amyloid secretase pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
PathWhiz Pathway Gastric Acid ProductionPW000564:Muscle/Heart Contraction
Reactome Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
G alpha (i) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP706:SIDS Susceptibility Pathways
GPCRs, OtherWP58:Monoamine GPCRs
Secretion of Hydrochloric Acid in Parietal Cells
GPCR downstream signalingWP58:Monoamine GPCRs
References
Ref 533345J Med Chem. 1989 May;32(5):1057-62.Synthesis and biological evaluation of [125I]- and [123I]-4-iododexetimide, a potent muscarinic cholinergic receptor antagonist.
Ref 533345J Med Chem. 1989 May;32(5):1057-62.Synthesis and biological evaluation of [125I]- and [123I]-4-iododexetimide, a potent muscarinic cholinergic receptor antagonist.

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