Drug Information

Drug General Information
Drug ID
D05KSW
Former ID
DNC013425
Drug Name
N-phenethylquinoxaline-2-carboxamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528497]
Structure
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2D MOL

3D MOL
Formula
C17H15N3O
Canonical SMILES
C1=CC=C(C=C1)CCNC(=O)C2=NC3=CC=CC=C3N=C2
InChI
1S/C17H15N3O/c21-17(18-11-10-13-6-2-1-3-7-13)16-12-19-14-8-4-5-9-15(14)20-16/h1-9,12H,10-11H2,(H,18,21)
InChIKey
VCRCXANKNYQHIW-UHFFFAOYSA-N
PubChem Compound ID
5300647
Target and Pathway
Target(s) Metabotropicglutamate receptor 1 Target Info Inhibitor [528497]
KEGG Pathway Calcium signaling pathway
FoxO signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Long-term depression
Estrogen signaling pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 528497Bioorg Med Chem Lett. 2007 Jan 15;17(2):486-90. Epub 2006 Oct 11.Structure-activity relationships of novel non-competitive mGluR1 antagonists: a potential treatment for chronic pain.
Ref 528497Bioorg Med Chem Lett. 2007 Jan 15;17(2):486-90. Epub 2006 Oct 11.Structure-activity relationships of novel non-competitive mGluR1 antagonists: a potential treatment for chronic pain.

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