Drug General Information
Drug ID	D05MDY
Former ID	DNC012765
Drug Name	2,8-Dimethyl-1-oxa-8-aza-spiro[4.5]decan-3-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[534723]
Structure		Download 2D MOL 3D MOL
Formula	C10H17NO2
Canonical SMILES	CC1C(=O)CC2(O1)CCN(CC2)C
InChI	1S/C10H17NO2/c1-8-9(12)7-10(13-8)3-5-11(2)6-4-10/h8H,3-7H2,1-2H3
InChIKey	OODDNJQTVFMGCF-UHFFFAOYSA-N
PubChem Compound ID	10176401
Target and Pathway
Target(s)	Muscarinic acetylcholine receptor M4	Target Info	Inhibitor	[534723]
	Muscarinic acetylcholine receptor M5	Target Info	Inhibitor	[534723]
	Muscarinic acetylcholine receptor M2	Target Info	Inhibitor	[534723]
	Muscarinic acetylcholine receptor M1	Target Info	Inhibitor	[534723]
	Muscarinic acetylcholine receptor M3	Target Info	Inhibitor	[534723]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Cholinergic synapse
	Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
	cAMP signaling pathway
	PI3K-Akt signaling pathway
	Regulation of actin cytoskeleton
	Insulin secretion
	Salivary secretion
	Gastric acid secretion
	Pancreatic secretion
PANTHER Pathway	Alzheimer disease-amyloid secretase pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Muscarinic acetylcholine receptor 2 and 4 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathwayP00003:Alzheimer disease-amyloid secretase pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
PathWhiz Pathway	Muscle/Heart ContractionPW000565:Gastric Acid Production
Reactome	Muscarinic acetylcholine receptors
	G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
	G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
	Acetylcholine regulates insulin secretion
	G alpha (q) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	Regulation of Actin Cytoskeleton
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signalingWP58:Monoamine GPCRs
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR downstream signalingWP706:SIDS Susceptibility Pathways
	GPCR downstream signaling
	GPCRs, OtherWP58:Monoamine GPCRs
	Secretion of Hydrochloric Acid in Parietal Cells
	Integration of energy metabolism
	GPCRs, Other
References
Ref 534723	J Med Chem. 1998 Oct 22;41(22):4181-5.Synthesis and modeling studies of a potent conformationally rigid muscarinic agonist: 1-azabicyclo[2.2.1]heptanespirofuranone.
Ref 534723	J Med Chem. 1998 Oct 22;41(22):4181-5.Synthesis and modeling studies of a potent conformationally rigid muscarinic agonist: 1-azabicyclo[2.2.1]heptanespirofuranone.

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