Drug Information

Drug General Information
Drug ID
D06GCP
Former ID
DIB002034
Drug Name
PSD-506
Synonyms
Muscarinic M2 antagonists, Roche; Ro-320-2904; M2/M3 muscarinic antagonists (benign prostate hyperplasia), Roche/Plethora; M2/M3 muscarinic antagonists (overactive bladder), Roche/Plethora; M2/M3 muscarinic antagonists (urge incontinence), Roche/Plethora; M2/M3 muscarinic antagonists (urological disorders), Roche/Plethora
Indication Overactive bladder disorder [ICD9: 188, 596.51; ICD10:C67, N32.81] Discontinued in Phase 2 [548196]
Company
Roche Bioscience
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M2 Target Info Modulator [1572591]
Muscarinic acetylcholine receptor M3 Target Info Modulator [1572591]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
Regulation of actin cytoskeleton
Insulin secretion
Salivary secretion
Gastric acid secretion
Pancreatic secretion
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
PathWhiz Pathway Muscle/Heart ContractionPW000565:Gastric Acid Production
Reactome Muscarinic acetylcholine receptors
G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling events
WikiPathways SIDS Susceptibility Pathways
Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP58:Monoamine GPCRs
Gastrin-CREB signalling pathway via PKC and MAPK
Integration of energy metabolism
GPCRs, Other
References
Ref 548196Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022973)
Ref 1572591Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.

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