Drug Information

Drug General Information
Drug ID
D06GNR
Former ID
DNC013424
Drug Name
N-(2-methyl-2-phenylpropyl)pyrazine-2-carboxamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528497]
Structure
Download
2D MOL

3D MOL
Formula
C15H17N3O
Canonical SMILES
CC(C)(CNC(=O)C1=NC=CN=C1)C2=CC=CC=C2
InChI
1S/C15H17N3O/c1-15(2,12-6-4-3-5-7-12)11-18-14(19)13-10-16-8-9-17-13/h3-10H,11H2,1-2H3,(H,18,19)
InChIKey
HMOMSNPWNJNCOE-UHFFFAOYSA-N
PubChem Compound ID
36039661
Target and Pathway
Target(s) Metabotropicglutamate receptor 1 Target Info Inhibitor [528497]
KEGG Pathway Calcium signaling pathway
FoxO signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Long-term depression
Estrogen signaling pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 528497Bioorg Med Chem Lett. 2007 Jan 15;17(2):486-90. Epub 2006 Oct 11.Structure-activity relationships of novel non-competitive mGluR1 antagonists: a potential treatment for chronic pain.
Ref 528497Bioorg Med Chem Lett. 2007 Jan 15;17(2):486-90. Epub 2006 Oct 11.Structure-activity relationships of novel non-competitive mGluR1 antagonists: a potential treatment for chronic pain.

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