Drug General Information
Drug ID	D06GPP
Former ID	DNC014101
Drug Name	(E)-4,4-Dimethyl-1-quinolin-3-yl-pent-1-en-3-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530245]
Structure		Download 2D MOL 3D MOL
Formula	C16H17NO
Canonical SMILES	CC(C)(C)C(=O)C=CC1=CC2=CC=CC=C2N=C1
InChI	1S/C16H17NO/c1-16(2,3)15(18)9-8-12-10-13-6-4-5-7-14(13)17-11-12/h4-11H,1-3H3/b9-8+
InChIKey	XROFVTPRFZVYMN-CMDGGOBGSA-N
PubChem Compound ID	11644388
Target and Pathway
Target(s)	Metabotropicglutamate receptor 1	Target Info	Inhibitor	[530245]
KEGG Pathway	Calcium signaling pathway
	FoxO signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Long-term potentiation
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Long-term depression
	Estrogen signaling pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Endogenous cannabinoid signaling
Reactome	G alpha (q) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	Hypothetical Network for Drug Addiction
	GPCRs, Class C Metabotropic glutamate, pheromone
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 530245	Bioorg Med Chem. 2009 Aug 1;17(15):5708-15. Epub 2009 Jun 23.Synergism of virtual screening and medicinal chemistry: identification and optimization of allosteric antagonists of metabotropic glutamate receptor 1.
Ref 530245	Bioorg Med Chem. 2009 Aug 1;17(15):5708-15. Epub 2009 Jun 23.Synergism of virtual screening and medicinal chemistry: identification and optimization of allosteric antagonists of metabotropic glutamate receptor 1.

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