| Drug General Information |
| Drug ID |
D06PRT
|
| Former ID |
DNC002436
|
| Drug Name |
Phosphonoserine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C3H8NO6P
|
| Canonical SMILES |
C(C(C(=O)O)N)OP(=O)(O)O
|
| InChI |
1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1
|
| InChIKey |
BZQFBWGGLXLEPQ-REOHCLBHSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
4251, 825453, 841619, 7890432, 7980684, 8145118, 8192381, 11113423, 15340053, 17405445, 24277998, 26751660, 29203220, 43125355, 46505297, 46517825, 47440569, 50068315, 50104360, 50104361, 53777992, 56435316, 56435317, 56435318, 57317099, 57410966, 79764880, 85165191, 85240002, 87574914, 90341677, 91701988, 92298672, 92304275, 103204663, 103843432, 104343198, 117626830, 121361478, 121362097, 124750074, 124886904, 126523129, 127591104, 131331990, 132521938, 135028622, 135651511, 135676490, 136023595
|
| Target and Pathway |
| Target(s) |
3-phosphoinositide dependent protein kinase-1 |
Target Info |
Inhibitor |
[1]
|
|---|
| Phosphomannomutase/phosphoglucomutase |
Target Info |
Inhibitor |
[1]
|
| Glycogen phosphorylase, muscle form |
Target Info |
Inhibitor |
[1]
|
| Rhodopsin |
Target Info |
Inhibitor |
[1]
|
| Protein kinase C, theta type |
Target Info |
Inhibitor |
[1]
|
|
BioCyc Pathway
|
Glycogenolysis
|
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KEGG Pathway
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PPAR signaling pathway
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FoxO signaling pathway
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Sphingolipid signaling pathway
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mTOR signaling pathway
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PI3K-Akt signaling pathway
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AMPK signaling pathway
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Focal adhesion
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T cell receptor signaling pathway
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Fc epsilon RI signaling pathway
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Neurotrophin signaling pathway
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Insulin signaling pathway
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Thyroid hormone signaling pathway
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Aldosterone-regulated sodium reabsorption
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Toxoplasmosis
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Hepatitis C
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Proteoglycans in cancer
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Endometrial cancer
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Prostate cancer
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Non-small cell lung cancer
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Choline metabolism in cancerhsa00500:Starch and sucrose metabolism
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Metabolic pathways
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Glucagon signaling pathwayhsa04744:Phototransductionhsa04064:NF-kappa B signaling pathway
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Vascular smooth muscle contraction
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Tight junction
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Inflammatory mediator regulation of TRP channels
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Adipocytokine signaling pathway
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Measles
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PANTHER Pathway
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Inflammation mediated by chemokine and cytokine signaling pathway
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Insulin/IGF pathway-protein kinase B signaling cascade
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Interleukin signaling pathway
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PDGF signaling pathway
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PI3 kinase pathway
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p53 pathway
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Ras Pathway
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p53 pathway feedback loops 2
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CCKR signaling map STP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00028:Heterotrimeric G-protein signaling pathway-rod outer segment phototransductionP00003:Alzheimer disease-amyloid secretase pathway
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Angiogenesis
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Apoptosis signaling pathway
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EGF receptor signaling pathway
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Endothelin signaling pathway
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FGF signaling pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Muscarinic acetylcholine receptor 1 and 3 signaling pathway
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T cell activation
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VEGF signaling pathway
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Wnt signaling pathway
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5HT2 type receptor mediated signaling pathway
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Histamine H1 receptor mediated signaling pathway
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Oxytocin receptor mediated signaling pathway
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Thyrotropin-releasing hormone receptor signaling pathway
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CCKR signaling map ST
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Pathway Interaction Database
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BCR signaling pathway
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Insulin Pathway
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TCR signaling in naï
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Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
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TCR signaling in naï
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FAS (CD95) signaling pathway
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mTOR signaling pathway
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CXCR4-mediated signaling events
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IGF1 pathway
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Class I PI3K signaling events
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ErbB1 downstream signaling
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IL8- and CXCR2-mediated signaling events
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CXCR3-mediated signaling events
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VEGFR1 specific signals
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Signaling events mediated by Stem cell factor receptor (c-Kit)
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Signaling events mediated by VEGFR1 and VEGFR2
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Class I PI3K signaling events mediated by Akt
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IL8- and CXCR1-mediated signaling events
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Trk receptor signaling mediated by PI3K and PLC-gamma
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FGF signaling pathway
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TGF-beta receptor signalingrhodopsin_pathway:Visual signal transduction: Rodsendothelinpathway:Endothelins
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Calcineurin-regulated NFAT-dependent transcription in lymphocytes
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Thromboxane A2 receptor signaling
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Role of Calcineurin-dependent NFAT signaling in lymphocytes
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Downstream signaling in naï
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PathWhiz Pathway
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Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
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Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
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Insulin Signalling
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Reactome
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GPVI-mediated activation cascade
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PIP3 activates AKT signaling
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Activation of AKT2
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Role of LAT2/NTAL/LAB on calcium mobilization
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FCERI mediated NF-kB activation
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Integrin alphaIIb beta3 signaling
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CD28 dependent PI3K/Akt signaling
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CTLA4 inhibitory signaling
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G beta:gamma signalling through PI3Kgamma
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VEGFR2 mediated vascular permeability
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VEGFR2 mediated cell proliferation
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CLEC7A (Dectin-1) signaling
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RHO GTPases activate PKNs
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Constitutive Signaling by AKT1 E17K in CancerR-HSA-2453902:The canonical retinoid cycle in rods (twilight vision)
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Inactivation, recovery and regulation of the phototransduction cascade
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G alpha (i) signalling eventsR-HSA-111465:Apoptotic cleavage of cellular proteins
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Effects of PIP2 hydrolysis
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G alpha (z) signalling events
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WikiPathways
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Serotonin HTR1 Group and FOS Pathway
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TCR Signaling Pathway
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Insulin Signaling
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EGF/EGFR Signaling Pathway
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Focal Adhesion
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Cardiac Hypertrophic Response
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Fc epsilon receptor (FCERI) signaling
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Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
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Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
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PIP3 activates AKT signaling
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BDNF signaling pathway
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Interleukin-11 Signaling Pathway
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B Cell Receptor Signaling Pathway
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Signaling Pathways in Glioblastoma
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TSH signaling pathway
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TCR signaling
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Signaling by Insulin receptor
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Integrin-mediated Cell Adhesion
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GPVI-mediated activation cascade
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GPCR downstream signaling
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Costimulation by the CD28 family
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MicroRNAs in cardiomyocyte hypertrophyWP500:Glycogen Metabolism
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Metabolism of carbohydratesWP455:GPCRs, Class A Rhodopsin-like
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Visual phototransduction
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Regulation of Microtubule Cytoskeleton
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Integrated Breast Cancer Pathway
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Integrin-mediated Cell AdhesionWP69:TCR Signaling Pathway
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Calcium Regulation in the Cardiac Cell
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Wnt Signaling Pathway
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Wnt Signaling Pathway and Pluripotency
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G Protein Signaling Pathways
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Myometrial Relaxation and Contraction Pathways
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Corticotropin-releasing hormone
|
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miRs in Muscle Cell Differentiation
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Netrin-1 signaling
|
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Effects of PIP2 hydrolysis
|
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Apoptotic execution phase
|
| References |
| REF 1 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. |
|---|
