Target Information
Target General Infomation | |||||
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Target ID |
T10091
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Former ID |
TTDR00221
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Target Name |
Rhodopsin
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Gene Name |
RHO
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Synonyms |
Opsin-2; RHO
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Target Type |
Research
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Disease | Cancer [ICD9: 140-229; ICD10: C00-C96] | ||||
Function |
Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal.
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BioChemical Class |
GPCR rhodopsin
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Target Validation |
T10091
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UniProt ID | |||||
Sequence |
MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLY
VTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLG GEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWSRYIP EGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIIIFFCYGQLVFTVKEAAAQQQES ATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTIPAFFAKSAAI YNPVIYIMMNKQFRNCMLTTICCGKNPLGDDEASATVSKTETSQVAPA |
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Inhibitor | (Hydroxyethyloxy)Tri(Ethyloxy)Octane | Drug Info | [551393] | ||
Alpha-D-Mannose | Drug Info | [551393] | |||
B-2-Octylglucoside | Drug Info | [551393] | |||
B-Nonylglucoside | Drug Info | [551374] | |||
B-Octylglucoside | Drug Info | [551393] | |||
Beta-D-Mannose | Drug Info | [551393] | |||
Heptane-1,2,3-Triol | Drug Info | [551393] | |||
Heptyl 1-Thiohexopyranoside | Drug Info | [551374] | |||
Hexadecanal | Drug Info | [551391] | |||
Lauryl Dimethylamine-N-Oxide | Drug Info | [551393] | |||
N-Acetylmethionine | Drug Info | [551374] | |||
NSC-88915 | Drug Info | [529643] | |||
Palmitic Acid | Drug Info | [551393] | |||
Phosphonoserine | Drug Info | [551393] | |||
Phosphonothreonine | Drug Info | [551393] | |||
Pathways | |||||
KEGG Pathway | Phototransduction | ||||
PANTHER Pathway | Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction | ||||
Pathway Interaction Database | Rods | ||||
Reactome | The canonical retinoid cycle in rods (twilight vision) | ||||
Inactivation, recovery and regulation of the phototransduction cascade | |||||
G alpha (i) signalling events | |||||
WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
Visual phototransduction | |||||
Regulation of Microtubule Cytoskeleton | |||||
Integrated Breast Cancer Pathway | |||||
Integrin-mediated Cell Adhesion | |||||
References | |||||
Ref 529643 | J Med Chem. 2008 Sep 11;51(17):5297-303. Epub 2008 Aug 16.Modulating G-protein coupled receptor/G-protein signal transduction by small molecules suggested by virtual screening. |
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