Drug Information

Drug General Information
Drug ID
D07KHH
Former ID
DCL000861
Drug Name
LAS-34273
Synonyms
Bretaris; Eklira; Aclidinium bromide; LAS-W-330; [1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]oct-8-yl] 2-hydroxy-2,2-dithiophen-2-yl-acetate Bromide
Drug Type
Small molecular drug
Indication Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10:J40-J44, J47] Approved [530127], [532210]
Company
Almirall
Structure
Download
2D MOL

3D MOL
Formula
C26H30BrNO4S2
Canonical SMILES
C1C[N+]2(CCC1C(C2)OC(=O)C(C3=CC=CS3)(C4=CC=CS4)O)CCCOC5<br />=CC=CC=C5.[Br-]
InChI
1S/C26H30NO4S2.BrH/c28-25(26(29,23-9-4-17-32-23)24-10-5-18-33-24)31-22-19-27(14-11-20(22)12-15-27)13-6-16-30-21-7-2-1-3-8-21;/h1-5,7-10,17-18,20,22,29H,6,11-16,19H2;1H/q+1;/p-1/t20?,22-,27?;/m0./s1
InChIKey
XLAKJQPTOJHYDR-QTQXQZBYSA-M
CAS Number
CAS 320345-99-1
PubChem Compound ID
11519741
PubChem Substance ID
16621631, 16789675, 23647592, 49684225, 74832104, 85252647, 96025520, 103688430, 134339211, 134339322, 135251922, 152258554, 160644963, 160647388, 163415577, 163849434, 164178043, 164785032, 175268353, 184811783, 189053466, 196409736, 198993056, 224334950, 226088015, 226452839, 241070489, 252470297
SuperDrug ATC ID
R03BB05
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M3 Target Info Antagonist [536223]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeleton
Insulin secretion
Salivary secretion
Gastric acid secretion
Pancreatic secretion
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
PathWhiz Pathway Gastric Acid Production
Reactome Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 530127Aclidinium bromide, a novel long-acting muscarinic M3 antagonist for the treatment of COPD. Curr Opin Investig Drugs. 2009 May;10(5):482-90.
Ref 532210Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
Ref 536223Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91.

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