Drug Information
Drug General Information | |||||
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Drug ID |
D07SGB
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Former ID |
DIB005245
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Drug Name |
ABT-299
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Synonyms |
A-85783
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Drug Type |
Small molecular drug
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Indication | Septic shock [ICD9: 785.52; ICD10:A41.9] | Discontinued in Phase 1 | [1], [2] | ||
Company |
Abbott Laboratories
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Structure |
Download2D MOL |
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Formula |
C32H28ClFN4O4S
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InChI |
InChI=1S/C32H28FN4O4S.ClH/c1-20(38)41-19-35-13-4-5-23(16-35)31-36-14-12-26(29(36)18-42-31)30(39)27-17-37(32(40)34(2)3)28-15-22(8-11-25(27)28)21-6-9-24(33)10-7-21;/h4-17,31H,18-19H2,1-3H3;1H/q+1;/p-1/t31-;/m1./s1
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InChIKey |
NKIONDJYXPXFFL-JSSVAETHSA-M
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Platelet-activating factor receptor | Target Info | Antagonist | [3] | |
KEGG Pathway | Calcium signaling pathway | ||||
Neuroactive ligand-receptor interaction | |||||
Staphylococcus aureus infection | |||||
NetPath Pathway | IL5 Signaling Pathway | ||||
Leptin Signaling Pathway | |||||
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (q) signalling events | |||||
Interferon gamma signaling | |||||
WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
Gastrin-CREB signalling pathway via PKC and MAPK | |||||
Small Ligand GPCRs | |||||
Interferon gamma signaling | |||||
GPCR ligand binding | |||||
GPCR downstream signaling | |||||
References | |||||
REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1849). | ||||
REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005514) | ||||
REF 3 | ABT-299, a novel PAF antagonist, attenuates multiple effects of endotoxemia in conscious rats. Shock. 1996 Aug;6(2):112-7. | ||||
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