Drug General Information
Drug ID	D07VZG
Former ID	DNC012594
Drug Name	BRL-55473
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[551234]
Structure		Download 2D MOL 3D MOL
Formula	C10H16ClN3O
Canonical SMILES	CON=C(C#N)C1CN2CCC1CC2.Cl
InChI	1S/C10H15N3O.ClH/c1-14-12-10(6-11)9-7-13-4-2-8(9)3-5-13;/h8-9H,2-5,7H2,1H3;1H/b12-10+;
InChIKey	INJWRVWKJFJRFO-VHPXAQPISA-N
PubChem Compound ID	9816017
Target and Pathway
Target(s)	Muscarinic acetylcholine receptor M4	Target Info	Inhibitor	[551234]
	Muscarinic acetylcholine receptor M5	Target Info	Inhibitor	[551234]
	Muscarinic acetylcholine receptor M3	Target Info	Inhibitor	[551234]
	Muscarinic acetylcholine receptor M2	Target Info	Inhibitor	[551234]
	Muscarinic acetylcholine receptor M1	Target Info	Inhibitor	[551234]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Cholinergic synapse
	Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
	Regulation of actin cytoskeleton
	Insulin secretion
	Salivary secretion
	Gastric acid secretion
	Pancreatic secretionhsa04020:Calcium signaling pathway
	cAMP signaling pathway
	PI3K-Akt signaling pathway
PANTHER Pathway	Alzheimer disease-amyloid secretase pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Muscarinic acetylcholine receptor 2 and 4 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathwayP00003:Alzheimer disease-amyloid secretase pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
PathWhiz Pathway	Gastric Acid ProductionPW000564:Muscle/Heart Contraction
Reactome	Muscarinic acetylcholine receptors
	G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
	G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
	Acetylcholine regulates insulin secretion
	G alpha (q) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	Regulation of Actin Cytoskeleton
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signalingWP58:Monoamine GPCRs
	Gastrin-CREB signalling pathway via PKC and MAPK
	Integration of energy metabolism
	GPCR downstream signaling
	GPCRs, OtherWP706:SIDS Susceptibility Pathways
	GPCRs, OtherWP58:Monoamine GPCRs
	Secretion of Hydrochloric Acid in Parietal Cells
References
Ref 551234	A novel and selective class of azabicyclic muscarinic agonists incorporating an N-methoxy imidoyl halide or nitrile functionality, Bioorg. Med. Chem. Lett. 2(8):791-796 (1992).
Ref 551234	A novel and selective class of azabicyclic muscarinic agonists incorporating an N-methoxy imidoyl halide or nitrile functionality, Bioorg. Med. Chem. Lett. 2(8):791-796 (1992).

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.