Drug Information

Drug General Information
Drug ID
D08KCA
Former ID
DNC000872
Drug Name
Leupeptin
Drug Type
Small molecular drug
Indication Malaria [ICD10:B54] Investigative [536365]
Structure
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2D MOL

3D MOL
Formula
C20H38N6O4
Canonical SMILES
CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CCCN=C(N)N)C=O)NC(=O)C
InChI
1S/C20H38N6O4/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23)/t15?,16-,17?/m0/s1
InChIKey
GDBQQVLCIARPGH-CGZBRXJRSA-N
CAS Number
CAS 103476-89-7
PubChem Compound ID
439527
PubChem Substance ID
36883733, 77099926, 104620729, 135021935, 184582471, 223440158
Target and Pathway
Target(s) Cysteine protease falcipain-2 Target Info Inhibitor [536636]
Plasmepsin 1 Target Info Inhibitor [536365]
Plasmepsin 2 Target Info Inhibitor [536365]
Falcipain-3 Target Info Inhibitor [536365]
References
Ref 536365Novel molecular targets for antimalarial chemotherapy. Int J Antimicrob Agents. 2007 Jul;30(1):4-10. Epub 2007 Mar 6.
Ref 536365Novel molecular targets for antimalarial chemotherapy. Int J Antimicrob Agents. 2007 Jul;30(1):4-10. Epub 2007 Mar 6.
Ref 536636Novel molecular targets for antimalarial drug development. Chem Biol Drug Des. 2008 Apr;71(4):287-97. Epub 2008 Feb 22.

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