Target Information

Target General Infomation
Target ID
T44614
Former ID
TTDR00606
Target Name
Cysteine protease falcipain-2
Gene Name
PFMG_03053
Synonyms
Falcipain-2; PFMG_03053
Target Type
Discontinued
Disease Infection of P. falciparum [ICD9: 84; ICD10: B50-B54]
Malaria [ICD10: B54]
BioChemical Class
Protease
Target Validation
T44614
UniProt ID
A0A0L1IBZ3
Sequence
MDYNMDYAPHEVISHQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFILFYFTPNFR
KSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNN
NADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPN
EMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKY
LLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAI
RKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICTDDDYPYVSDAPNLCNID
RCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDELNHAVM
LVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFI
PLIE
Drugs and Mode of Action
Drug(s) MDL-2170 Drug Info Terminated Discovery agent [545554]
Pepstatin Drug Info Terminated Malaria [545704]
Inhibitor FITC-LMNNAEHINQFYMFI Drug Info [529457]
Leupeptin Drug Info [536636]
MDL-2170 Drug Info [528208]
Pepstatin Drug Info [536636]
Binder Vinylsulphones Drug Info [536135]
References
Ref 545554Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003692)
Ref 545704Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004280)
Ref 528208J Med Chem. 2006 Jun 1;49(11):3064-7.Novel peptidomimetic cysteine protease inhibitors as potential antimalarial agents.
Ref 529457J Med Chem. 2008 Jun 12;51(11):3116-23. Epub 2008 May 8.A prodomain peptide of Plasmodium falciparum cysteine protease (falcipain-2) inhibits malaria parasite development.
Ref 536135Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005 Sep;4(9):727-40.
Ref 536636Novel molecular targets for antimalarial drug development. Chem Biol Drug Des. 2008 Apr;71(4):287-97. Epub 2008 Feb 22.

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