Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T44614
|
||||
| Former ID |
TTDR00606
|
||||
| Target Name |
Cysteine protease falcipain-2
|
||||
| Gene Name |
PFMG_03053
|
||||
| Synonyms |
Falcipain-2; PFMG_03053
|
||||
| Target Type |
Discontinued
|
||||
| Disease | Infection of P. falciparum [ICD9: 84; ICD10: B50-B54] | ||||
| Malaria [ICD10: B54] | |||||
| BioChemical Class |
Protease
|
||||
| Target Validation |
T44614
|
||||
| UniProt ID | |||||
| Sequence |
MDYNMDYAPHEVISHQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFILFYFTPNFR
KSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNN NADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPN EMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKY LLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAI RKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICTDDDYPYVSDAPNLCNID RCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDELNHAVM LVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFI PLIE |
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| Drugs and Mode of Action | |||||
| Drug(s) | MDL-2170 | Drug Info | Terminated | Discovery agent | [1] |
| Pepstatin | Drug Info | Terminated | Malaria | [2] | |
| Inhibitor | FITC-LMNNAEHINQFYMFI | Drug Info | [3] | ||
| Leupeptin | Drug Info | [4] | |||
| MDL-2170 | Drug Info | [5] | |||
| Pepstatin | Drug Info | [4] | |||
| Binder | Vinylsulphones | Drug Info | [6] | ||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003692) | ||||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004280) | ||||
| REF 3 | J Med Chem. 2008 Jun 12;51(11):3116-23. Epub 2008 May 8.A prodomain peptide of Plasmodium falciparum cysteine protease (falcipain-2) inhibits malaria parasite development. | ||||
| REF 4 | Novel molecular targets for antimalarial drug development. Chem Biol Drug Des. 2008 Apr;71(4):287-97. Epub 2008 Feb 22. | ||||
| REF 5 | J Med Chem. 2006 Jun 1;49(11):3064-7.Novel peptidomimetic cysteine protease inhibitors as potential antimalarial agents. | ||||
| REF 6 | Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005 Sep;4(9):727-40. | ||||
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