Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D08ORO
|
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| Former ID |
DNC001062
|
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| Drug Name |
OPC-21268
|
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| Drug Type |
Small molecular drug
|
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| Indication | Cardiotonic [ICD10:I50] | Discontinued in Phase 2 | [1], [2] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C26H31N3O4
|
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| InChI |
InChI=1S/C26H31N3O4/c1-19(30)27-15-4-18-33-23-10-7-21(8-11-23)26(32)28-16-13-22(14-17-28)29-24-6-3-2-5-20(24)9-12-25(29)31/h2-3,5-8,10-11,22H,4,9,12-18H2,1H3,(H,27,30)
|
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| InChIKey |
KSNUCNRMDYJBKT-UHFFFAOYSA-N
|
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| CAS Number |
CAS 131631-89-5
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Vasopressin V1a receptor | Target Info | Antagonist | [3], [4] | |
| Vasopressin V1 receptor | Target Info | Antagonist | [5] | ||
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Vascular smooth muscle contraction | |||||
| Reactome | Vasopressin-like receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2196). | ||||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000284) | ||||
| REF 3 | Nonpeptide vasopressin antagonists: a new group of hormone blockers entering the scene. Exp Clin Endocrinol Diabetes. 1999;107(3):157-65. | ||||
| REF 4 | Nonpeptide vasopressin receptor antagonists: development of selective and orally active V1a, V2 and V1b receptor ligands. Prog Brain Res. 2002;139:197-210. | ||||
| REF 5 | Vasopressin (ADH). Nippon Rinsho. 1992 Dec;50(12):2893-900. | ||||
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