Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09MON
|
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| Former ID |
DIB011328
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| Drug Name |
A-75998
|
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| Indication | Hormone deficiency [ICD10:E00-E90] | Discontinued in Phase 1 | [1] | ||
| Company |
Abbott Laboratories
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| Structure |
|
Download2D MOL |
|||
| Formula |
C80H104ClN15O14
|
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| Canonical SMILES |
N1(C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](N(<br />C(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)C<br />)Cc2cc3c(cc2)cccc3)Cc2ccc(Cl)cc2)Cc2cnccc2)CO)C)Cc2ccc(<br />cc2)O)CCCCNC(=O)c2cnccc2)CC(C)C)CCCCNC(C)C)[C@H](C(=O)N<br />[C@@H](C(=O)N)C)CCC1
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| CAS Number |
CAS 135215-95-1
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Gonadotropin-releasing hormone receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| GnRH signaling pathway | |||||
| NetPath Pathway | IL1 Signaling Pathway | ||||
| IL2 Signaling Pathway | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
| Reactome | Hormone ligand-binding receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003694) | ||||
| REF 2 | Physicochemical properties of A-75998, an antagonist of luteinizing hormone releasing hormone. J Pharm Sci. 1995 Aug;84(8):953-8. | ||||
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