Drug Information

Drug General Information
Drug ID
D09UMA
Former ID
DNC004281
Drug Name
IMAZODAN
Drug Type
Small molecular drug
Indication Discovery agent Terminated [544637]
Structure
Download
2D MOL

3D MOL
Formula
C13H13ClN4O
Canonical SMILES
C1CC(=O)NN=C1C2=CC=C(C=C2)N3C=CN=C3
InChI
1S/C13H12N4O/c18-13-6-5-12(15-16-13)10-1-3-11(4-2-10)17-8-7-14-9-17/h1-4,7-9H,5-6H2,(H,16,18)
InChIKey
VXMYWVMXSWJFCV-UHFFFAOYSA-N
PubChem Compound ID
55917
Target and Pathway
Target(s) CGMP-specific 3',5'-cyclic phosphodiesterase Target Info Inhibitor [533555]
CGMP-dependent3',5'-cyclic phosphodiesterase Target Info Inhibitor [533555]
CGMP-inhibited 3',5'-cyclic phosphodiesterase A Target Info Inhibitor [526726]
KEGG Pathway Purine metabolism
cGMP-PKG signaling pathwayhsa00230:Purine metabolism
cGMP-PKG signaling pathway
Morphine addictionhsa00230:Purine metabolism
cAMP signaling pathway
Morphine addiction
NetPath Pathway TGF_beta_Receptor Signaling PathwayNetPath_23:TSH Signaling Pathway
Reactome cGMP effectsR-HSA-418457:cGMP effects
G alpha (s) signalling eventsR-HSA-418457:cGMP effects
G alpha (s) signalling events
WikiPathways miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
References
Ref 544637Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000379)
Ref 526726J Med Chem. 1992 Feb 21;35(4):620-8.3,4-Dihydroquinolin-2(1H)-ones as combined inhibitors of thromboxane A2 synthase and cAMP phosphodiesterase.
Ref 533555J Med Chem. 1984 Sep;27(9):1099-101.Cardiotonic agents. 1. 4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3 (2H)-pyridazinones: novel positive inotropic agents for the treatment of congestive heart failure.

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