Target Information
Target General Infomation | |||||
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Target ID |
T77400
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Former ID |
TTDR00256
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Target Name |
CGMP-dependent3',5'-cyclic phosphodiesterase
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Gene Name |
PDE2A
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Synonyms |
CGS-PDE; CGSPDE; Cyclic GMP stimulated phosphodiesterase; Cyclic-GMP phosphodiesterase; PDE-II; PDE2A
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Target Type |
Clinical Trial
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Disease | Inflammatory bowel disease [ICD9: 555, 556; ICD10: K50, K51] | ||||
Mood disorder [ICD10: F30-F39] | |||||
Function |
Hydrolyzes both cyclic amp (camp) and cyclic gmp (cgmp).
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BioChemical Class |
Phosphoric diester hydrolases
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Target Validation |
T77400
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UniProt ID | |||||
EC Number |
EC 3.1.4.17
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Sequence |
MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDI
SGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCN GLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAV EKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDL DASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVV EDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTD EDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITE ARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPD AYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAF SIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNF ASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMH AFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYS SEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDL QKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAM GNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSH KFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE |
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Drugs and Mode of Action | |||||
Inhibitor | (2R,3S)-3-(6-Amino-purin-9-yl)-nonan-2-ol | Drug Info | [527549] | ||
2-Morpholin-4-yl-8-phenylethynyl-chromen-4-one | Drug Info | [527068] | |||
3-Isobutyl-1-methyl-3,9-dihydro-purine-2,6-dione | Drug Info | [533395] | |||
3-ISOBUTYL-1-METHYLXANTHINE | Drug Info | [551374] | |||
BAY-60-7550 | Drug Info | [527549] | |||
Benzyl-(2-pyridin-3-yl-quinazolin-4-yl)-amine | Drug Info | [533684] | |||
Benzyl-(2-pyridin-4-yl-quinazolin-4-yl)-amine | Drug Info | [533684] | |||
CP-461 | Drug Info | [535265] | |||
Cyclic Guanosine Monophosphate | Drug Info | [551393] | |||
EHNA | Drug Info | [534171] | |||
IMAZODAN | Drug Info | [533555] | |||
Modulator | ND7001 | Drug Info | [532028] | ||
Pathways | |||||
KEGG Pathway | Purine metabolism | ||||
cGMP-PKG signaling pathway | |||||
Morphine addiction | |||||
NetPath Pathway | TSH Signaling Pathway | ||||
Reactome | cGMP effects | ||||
G alpha (s) signalling events | |||||
References | |||||
Ref 527068 | Bioorg Med Chem Lett. 2004 Jun 7;14(11):2847-51.PDE2 inhibition by the PI3 kinase inhibitor LY294002 and analogues. | ||||
Ref 527549 | J Med Chem. 2005 May 19;48(10):3449-62.The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases. | ||||
Ref 532028 | Phosphodiesterase 2 inhibitors promote axonal outgrowth in organotypic slice co-cultures. Neurosignals. 2013;21(3-4):197-212. | ||||
Ref 533395 | J Med Chem. 1985 May;28(5):537-45.A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity. | ||||
Ref 533555 | J Med Chem. 1984 Sep;27(9):1099-101.Cardiotonic agents. 1. 4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3 (2H)-pyridazinones: novel positive inotropic agents for the treatment of congestive heart failure. | ||||
Ref 533684 | J Med Chem. 1995 Sep 1;38(18):3547-57.Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and thromboxane synthesis inhibitory activities. | ||||
Ref 534171 | Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T cell antigen receptor on thymocytes: analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram. Cell Signal. 1996 Feb;8(2):97-110. |
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