Drug Information

Drug General Information
Drug ID
D0U8YQ
Former ID
DNC011985
Drug Name
Benzyl-(2-pyridin-4-yl-quinazolin-4-yl)-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533684]
Structure
Download
2D MOL

3D MOL
Formula
C20H16N4
Canonical SMILES
C1=CC=C(C=C1)CNC2=NC(=NC3=CC=CC=C32)C4=CC=NC=C4
InChI
1S/C20H16N4/c1-2-6-15(7-3-1)14-22-20-17-8-4-5-9-18(17)23-19(24-20)16-10-12-21-13-11-16/h1-13H,14H2,(H,22,23,24)
InChIKey
NZWWYUMFUATSTK-UHFFFAOYSA-N
PubChem Compound ID
921562
Target and Pathway
Target(s) CAMP-specific 3',5'-cyclic phosphodiesterase 4B Target Info Inhibitor [533684]
CGMP-dependent3',5'-cyclic phosphodiesterase Target Info Inhibitor [533684]
CAMP-specific 3',5'-cyclic phosphodiesterase 4A Target Info Inhibitor [533684]
KEGG Pathway Purine metabolism
cAMP signaling pathway
Morphine addictionhsa00230:Purine metabolism
cGMP-PKG signaling pathway
Morphine addiction
NetPath Pathway IL5 Signaling Pathway
IL2 Signaling PathwayNetPath_23:TSH Signaling Pathway
Reactome DARPP-32 events
G alpha (s) signalling eventsR-HSA-418457:cGMP effects
G alpha (s) signalling eventsR-HSA-180024:DARPP-32 events
G alpha (s) signalling events
WikiPathways G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
Nuclear Receptors Meta-Pathway
Opioid SignallingWP35:G Protein Signaling Pathways
References
Ref 533684J Med Chem. 1995 Sep 1;38(18):3547-57.Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and thromboxane synthesis inhibitory activities.
Ref 533684J Med Chem. 1995 Sep 1;38(18):3547-57.Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and thromboxane synthesis inhibitory activities.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.