Drug Information

Drug General Information
Drug ID
D09LAQ
Former ID
DNC003186
Drug Name
Cyclic Guanosine Monophosphate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539488]
Structure
Download
2D MOL

3D MOL
Formula
C10H12N5O7P
InChI
InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/t3-,5-,6-,9-/m1/s1
InChIKey
ZOOGRGPOEVQQDX-UUOKFMHZSA-N
CAS Number
CAS 7665-99-8
PubChem Compound ID
24316
PubChem Substance ID
4194, 825087, 826483, 830045, 831843, 841464, 7885238, 7889740, 14900537, 16415368, 24778932, 26703232, 29291398, 49693485, 49746466, 49854172, 50096566, 50315835, 53777030, 53777035, 53777038, 53790146, 56311215, 57331663, 92298285, 103526857, 104359789, 121270428, 126523956, 129932460, 134988190, 135651454, 137231635, 137249688, 152256021, 160848229, 162221115, 163724378, 165248680, 172096870, 172097238, 175443186, 177012389, 184611498, 186009741, 188377283, 189158863, 198946721, 219402225, 223557137
Target and Pathway
Target(s) CGMP-dependent3',5'-cyclic phosphodiesterase Target Info Inhibitor [551393]
CAMP-dependent protein kinase type I-alpha regulatory chain Target Info Inhibitor [551393]
KEGG Pathway Purine metabolism
cGMP-PKG signaling pathway
Morphine addictionhsa04210:Apoptosis
Insulin signaling pathway
NetPath Pathway TSH Signaling PathwayNetPath_25:FSH Signaling Pathway
PANTHER Pathway Endothelin signaling pathway
Hedgehog signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group II pathway
Metabotropic glutamate receptor group I pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Transcription regulation by bZIP transcription factor
GABA-B receptor II signaling
Pathway Interaction Database Alpha4 beta1 integrin signaling events
PathWhiz Pathway Muscle/Heart Contraction
Reactome cGMP effects
G alpha (s) signalling eventsR-HSA-163615:PKA activation
PKA activation in glucagon signalling
DARPP-32 events
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Vasopressin regulates renal water homeostasis via Aquaporins
Hedgehog 'off' state
Factors involved in megakaryocyte development and platelet production
WikiPathways SIDS Susceptibility Pathways
Calcium Regulation in the Cardiac Cell
G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
Mesodermal Commitment Pathway
DAG and IP3 signaling
Regulation of Water Balance by Renal Aquaporins
miRs in Muscle Cell Differentiation
Opioid Signalling
Integration of energy metabolism
Factors involved in megakaryocyte development and platelet production
References
Ref 539488(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2347).
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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