Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0AC2H
|
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| Former ID |
DIB020085
|
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| Drug Name |
isonipecotic acid
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C6H11NO2
|
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| InChI |
InChI=1S/C6H11NO2/c8-6(9)5-1-3-7-4-2-5/h5,7H,1-4H2,(H,8,9)
|
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| InChIKey |
SRJOCJYGOFTFLH-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
108908, 3133581, 5621709, 8139887, 8152387, 11111343, 15114452, 17405266, 24278166, 24887575, 29200595, 29222892, 48259445, 49829676, 49986082, 50105710, 50105711, 51074881, 53777811, 57321988, 57636349, 76425231, 81041458, 85087068, 85231096, 87571621, 87623723, 90341183, 92304064, 103179764, 103914803, 104304478, 104667281, 117609573, 117650612, 117688725, 118053598, 121361695, 124749931, 124880480, 124880481, 125003175, 125321689, 125351469, 126557591, 126579288, 126588515, 126607407, 126614636, 126616726
|
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| Target and Pathway | |||||
| Target(s) | Gamma-aminobutyric-acid receptor alpha-2 subunit | Target Info | Agonist | [2] | |
| GABAA receptor rho2 subunit | Target Info | Antagonist | [3] | ||
| GABAA receptor rho3 subunit | Target Info | Antagonist | [4] | ||
| Gamma-aminobutyric-acid receptor alpha-3 subunit | Target Info | Agonist | [5] | ||
| GABAA receptor rho1 subunit | Target Info | Antagonist | [6] | ||
| Gamma-aminobutyric-acid receptor alpha-5 subunit | Target Info | Agonist | [7] | ||
| GABA A receptor | Target Info | Agonist | [8] | ||
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Retrograde endocannabinoid signaling | |||||
| GABAergic synapse | |||||
| Morphine addiction | |||||
| Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction | |||||
| Nicotine addiction | |||||
| Reactome | Ligand-gated ion channel transport | ||||
| GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport | |||||
| GABA A receptor activation | |||||
| WikiPathways | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||||
| Iron uptake and transportWP706:SIDS Susceptibility Pathways | |||||
| Iron uptake and transport | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4227). | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 405). | ||||
| REF 3 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 421). | ||||
| REF 4 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 422). | ||||
| REF 5 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 406). | ||||
| REF 6 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 420). | ||||
| REF 7 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 408). | ||||
| REF 8 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415). | ||||
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