Drug Information

Drug General Information
Drug ID
D0B2OT
Former ID
DAP000896
Drug Name
Isoflurophate
Synonyms
DFP; DIFP; Diflupyl; Diflurophate; Diisopropylfluorfosfat; Diisopropylfluorophosphate; Diisopropylfluorphosphorsaeureester; Diisopropylphosphofluoridate; Diisopropylphosphorofluoridate; Dyflos; Floropryl; Fluoropryl; Fluorostigmine; Fluostigmine; Fluropryl; Isofluorophate; Isofluorphate; Isoflurophosphate; Neoglaucit; Di isopropylphosphorofluoridate; Diisopropoxyphosphoryl fluoride; Diisopropyl fluoridophosphate; Diisopropyl fluorophosphate; Diisopropyl fluorophosphonate; Diisopropyl phosphofluoridate; Diisopropyl phosphorofluoridate; Diisopropylfluorfosfat [Czech]; Diisopropylfluorophosphoric acid ester; Diisopropylfluorphosphorsaeureester [German]; Disiopropyl fluorophosphonate; Fluorodiisopropyl phosphate; Isoflurophate [USP]; Isopropyl fluophosphate; Isopropyl phosphorofluoridate; Merck Brand of Isoflurophate; Phosphoric acid diisopropyl ester fluoride; EA 1152; TL 466; DIISOPROPYL-FLUOROPHOSPHATE; Di-isopropylphosphorofluoridate; Floropryl (TN); Fluophosphoric acid, diisopropyl ester; Fluorophosphoric acid, diisopropyl ester; Isoflurophate (USP); PF-3; Phosphorofluoridic acid, diisopropyl ester; T-1703; Bis(1-methylethyl) Phosphorofluoridate; Dipropan-2-yl phosphorofluoridoate; O,O-Diisopropyl fluorophosphate; Bis(propan-2-yl) fluorophosphate; O,O'-Diisopropyl phosphoryl fluoride; Phosphorofluoridic acid, bis(1-methylethyl) ester; 2-[fluoro(propan-2-yloxy)phosphoryl]oxypropane
Drug Type
Small molecular drug
Indication Glaucoma [ICD9: 365; ICD10:H40-H42] Approved [536300]
Therapeutic Class
Antiglaucomic Agents
Structure
Download
2D MOL

3D MOL
Formula
C6H14FO3P
Canonical SMILES
CC(C)OP(=O)(OC(C)C)F
InChI
1S/C6H14FO3P/c1-5(2)9-11(7,8)10-6(3)4/h5-6H,1-4H3
InChIKey
MUCZHBLJLSDCSD-UHFFFAOYSA-N
CAS Number
CAS 55-91-4
PubChem Compound ID
5936
PubChem Substance ID
3502, 3132931, 7640853, 7847111, 7979655, 8144556, 8153682, 10527274, 15042137, 24863641, 24893303, 26758613, 29224961, 46504128, 46504499, 47365440, 47440512, 47736736, 50009306, 50113285, 50885088, 53790824, 57288767, 57323062, 57392647, 103274564, 103933334, 104310665, 125414663, 126532445, 126678577, 128648130, 131540990, 134338173, 134972445, 137005316, 142731942, 144206196, 152187324, 160964022, 162872683, 163688227, 163781382, 176254456, 179148514, 184547868, 198978488, 202824756, 223673647, 226445171
ChEBI ID
ChEBI:17941
SuperDrug ATC ID
S01EB07
SuperDrug CAS ID
cas=000055914
Target and Pathway
Target(s) Acetylcholinesterase Target Info Inhibitor [535756]
KEGG Pathway Glycerophospholipid metabolism
Cholinergic synapse
PANTHER Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database ATF-2 transcription factor network
PathWhiz Pathway Phospholipid Biosynthesis
WikiPathways Monoamine Transport
Biogenic Amine Synthesis
Acetylcholine Synthesis
Integrated Pancreatic Cancer Pathway
References
Ref 536300Anaesthetic drugs: linking molecular actions to clinical effects. Curr Pharm Des. 2006;12(28):3665-79.
Ref 535756Rational design of alkylene-linked bis-pyridiniumaldoximes as improved acetylcholinesterase reactivators. Chem Biol. 2003 Jun;10(6):491-502.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.