Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0B8UJ
|
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| Former ID |
DAP000985
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| Drug Name |
Nelarabine
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| Synonyms |
Arranon; ArranonG; Atriance; Nelzarabine; Nelarabine [USAN]; Nelzarabine [USAN]; GW 506U78; GW506U78; U78; Arranon (GlaxoSmithKline); Arranon (TN); Arranon, Nelarabine; Atriance (TN); GW-506U; GW-506U78; Nelarabine (INN); Nelzarabine (USAN); O-Methoxydeoxyguanosine; O-Methylguanosine; Nelarabine (JAN/USAN); (2R,3R,4S,5R)-2-(2-amino-6-methoxypurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; (2R,3S,4S,5R)-2-(2-amino-6-methoxypurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; (3S,4S,5R)-2-(2-amino-6-methoxypurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; 2-(2-Amino-6-methoxy-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol; 2-(2-amino-6-methoxypurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; 2-Amino-6-methoxypurine arabinoside; 2-Amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine; 6'-O-Methylguanosine; 9-beta-D-Arabinofuranosyl-6-methoxy-9H-purin-2-amine; 9beta-D-Arabinofuranosyl-6-methoxy-9H-purin-2-amine
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| Drug Type |
Small molecular drug
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| Therapeutic Class |
Anticancer Agents
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| Company |
GlaxoSmithKline
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| Structure |
|
Download2D MOL |
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| Formula |
C11H15N5O5
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| InChI |
InChI=1S/C11H15N5O5/c1-20-9-5-8(14-11(12)15-9)16(3-13-5)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15)/t4-,6-,7+,10-/m1/s1
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| InChIKey |
IXOXBSCIXZEQEQ-UHTZMRCNSA-N
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| CAS Number |
CAS 121032-29-9
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| PubChem Compound ID | |||||
| PubChem Substance ID |
3723610, 10039476, 12015013, 14775959, 14922755, 36059494, 46506325, 47206859, 50125808, 57410212, 71821532, 80796537, 99437030, 103771095, 111631431, 124757087, 125163891, 126592934, 128235087, 131296361, 134223564, 134338255, 135108408, 135611106, 136368093, 136375852, 136949086, 137006687, 140519970, 144074932, 144115623, 144206267, 151991744, 152059610, 152213835, 152344115, 160964602, 162011505, 164175279, 170464759, 172914301, 174477095, 175266277, 176484949, 178103668, 179116965, 185998139, 196376328, 210274937, 210280574
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| SuperDrug ATC ID |
L01BB07
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| Target and Pathway | |||||
| Target(s) | DNA | Target Info | Binder | [536644] | |
| References | |||||
| Ref 536361 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. | ||||
| Ref 536644 | Nelarabine. Drugs. 2008;68(4):439-47. | ||||
| Ref 542096 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7090). | ||||
| Ref 551186 | 2005 approvals: Safety first. Nature Reviews Drug Discovery 5, 92-93 (February 2006). | ||||
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