Drug Information

Drug General Information
Drug ID
D0BZ7W
Former ID
DAP000376
Drug Name
Tolterodine
Synonyms
Tolterodina; Tolterodinum; Detrol (TN); Detrusitol (TN); Kabi-2234; 2-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-methylphenol; 2-[(1R)-3-[di(propan-2-yl)amino]-1-phenylpropyl]-4-methylphenol; 2-[3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-methylphenol; 2-{(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl}-4-methylphenol
Drug Type
Small molecular drug
Indication Overactive bladder [ICD9: 596.51; ICD10:N32.81] Approved [551871]
Therapeutic Class
Antispasmodics
Company
Pfizer Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C22H31NO
InChI
InChI=1S/C22H31NO/c1-16(2)23(17(3)4)14-13-20(19-9-7-6-8-10-19)21-15-18(5)11-12-22(21)24/h6-12,15-17,20,24H,13-14H2,1-5H3/t20-/m1/s1
InChIKey
OOGJQPCLVADCPB-HXUWFJFHSA-N
CAS Number
CAS 124937-51-5
PubChem Compound ID
443879
PubChem Substance ID
9952, 7847712, 14777260, 14801661, 23936567, 29215497, 36887062, 46508059, 48416646, 49666284, 50070814, 56322577, 56464111, 57404545, 75101389, 85083128, 89736135, 92712344, 93166476, 93618065, 103463555, 104050603, 104179074, 104630915, 118048147, 118048994, 124799394, 126625639, 126656774, 126668318, 127315558, 127315559, 127315560, 128837711, 135651269, 137028044, 140085486, 143493272, 144205290, 151981130, 152034997, 152236221, 164234496, 164765641, 164787750, 170465337, 172440007, 175265551, 176485082, 179116925
ChEBI ID
ChEBI:9622
SuperDrug ATC ID
G04BD07
SuperDrug CAS ID
cas=124937515
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M3 Target Info Antagonist [535660], [535903]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeleton
Insulin secretion
Salivary secretion
Gastric acid secretion
Pancreatic secretion
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
PathWhiz Pathway Gastric Acid Production
Reactome Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 535660Knockouts model the 100 best-selling drugs--will they model the next 100? Nat Rev Drug Discov. 2003 Jan;2(1):38-51.
Ref 535903Signal transduction underlying carbachol-induced contraction of human urinary bladder. J Pharmacol Exp Ther. 2004 Jun;309(3):1148-53. Epub 2004 Feb 9.

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