Drug Information

Drug General Information
Drug ID
D0C1OZ
Former ID
DNC001223
Drug Name
Ro092210
Indication Discovery agent Investigative [535353]
Target and Pathway
Target(s) Mitogen-activated protein kinase kinase kinase 2 Target Info Inhibitor [535353]
MEKK-1 kinase Target Info Inhibitor [535353]
KEGG Pathway MAPK signaling pathway
Gap junction
GnRH signaling pathwayhsa04010:MAPK signaling pathway
Ubiquitin mediated proteolysis
RIG-I-like receptor signaling pathway
Neurotrophin signaling pathway
GnRH signaling pathway
Hepatitis B
HTLV-I infection
NetPath Pathway IL5 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
TCR Signaling Pathway
PANTHER Pathway B cell activation
EGF receptor signaling pathway
FGF signaling pathwayP00005:Angiogenesis
Apoptosis signaling pathway
T cell activation
Ras Pathway
Pathway Interaction Database ErbB1 downstream signaling
Trk receptor signaling mediated by the MAPK pathwayfcer1pathway:Fc-epsilon receptor I signaling in mast cells
BCR signaling pathway
p38 MAPK signaling pathway
CD40/CD40L signaling
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Osteopontin-mediated events
TRAIL signaling pathway
CDC42 signaling events
FAS (CD95) signaling pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
TNF receptor signaling pathway
Ceramide signaling pathway
IFN-gamma pathway
JNK signaling in the CD4+ TCR pathway
Caspase Cascade in Apoptosis
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
RAC1 signaling pathway
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome MyD88:Mal cascade initiated on plasma membrane
FCERI mediated MAPK activation
TRAF6 mediated NF-kB activation
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 cascade initiated on plasma membrane
WikiPathways Insulin Signaling
EGF/EGFR Signaling Pathway
MAPK Cascade
MAPK Signaling Pathway
BDNF signaling pathway
IL-1 signaling pathwayWP722:Serotonin HTR1 Group and FOS Pathway
DNA Damage Response (only ATM dependent)
Interferon type I signaling pathways
p38 MAPK Signaling Pathway
Apoptosis Modulation by HSP70
FAS pathway and Stress induction of HSP regulation
MyD88 cascade initiated on plasma membrane
Cardiac Hypertrophic Response
MyD88 dependent cascade initiated on endosome
MyD88:Mal cascade initiated on plasma membrane
Fc epsilon receptor (FCERI) signaling
Structural Pathway of Interleukin 1 (IL-1)
Polycystic Kidney Disease Pathway
Apoptosis
PDGF Pathway
TNF alpha Signaling Pathway
IL-1 signaling pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
References
Ref 535353Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci. 2002 Jan;23(1):40-5.
Ref 535353Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci. 2002 Jan;23(1):40-5.

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