Target Information
| Target General Infomation | |||||
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| Target ID |
T06031
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| Former ID |
TTDNC00348
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| Target Name |
MEKK-1 kinase
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| Gene Name |
MAP3K1
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| Synonyms |
MAPK/ERK kinase kinase 1; MEK kinase 1; MEKK 1; Mitogenactivated protein kinase kinase kinase 1; MAP3K1
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| Target Type |
Research
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| Function |
Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.
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| BioChemical Class |
Kinase
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| UniProt ID | |||||
| EC Number |
EC 2.7.11.25
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| Sequence |
MAAAAGNRASSSGFPGARATSPEAGGGGGALKASSAPAAAAGLLREAGSGGRERADWRRR
QLRKVRSVELDQLPEQPLFLAASPPASSTSPSPEPADAAGSGTGFQPVAVPPPHGAASRG GAHLTESVAAPDSGASSPAAAEPGEKRAPAAEPSPAAAPAGREMENKETLKGLHKMDDRP EERMIREKLKATCMPAWKHEWLERRNRRGPVVVKPIPVKGDGSEMNHLAAESPGEVQASA ASPASKGRRSPSPGNSPSGRTVKSESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYS PEETNRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCARGTFCIHLLF VMLRVFQLEPSDPMLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNSHT LSSSSTSTSSSENSIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECR RNREPLICPLCRSKWRSHDFYSHELSSPVDSPSSLRAAQQQTVQQQPLAGSRRNQESNFN LTHYGTQQIPPAYKDLAEPWIQVFGMELVGCLFSRNWNVREMALRRLSHDVSGALLLANG ESTGNSGGSSGSSPSGGATSGSSQTSISGDVVEACCSVLSMVCADPVYKVYVAALKTLRA MLVYTPCHSLAERIKLQRLLQPVVDTILVKCADANSRTSQLSISTLLELCKGQAGELAVG REILKAGSIGIGGVDYVLNCILGNQTESNNWQELLGRLCLIDRLLLEFPAEFYPHIVSTD VSQAEPVEIRYKKLLSLLTFALQSIDNSHSMVGKLSRRIYLSSARMVTTVPHVFSKLLEM LSVSSSTHFTRMRRRLMAIADEVEIAEAIQLGVEDTLDGQQDSFLQASVPNNYLETTENS SPECTVHLEKTGKGLCATKLSASSEDISERLASISVGPSSSTTTTTTTTEQPKPMVQTKG RPHSQCLNSSPLSHHSQLMFPALSTPSSSTPSVPAGTATDVSKHRLQGFIPCRIPSASPQ TQRKFSLQFHRNCPENKDSDKLSPVFTQSRPLPSSNIHRPKPSRPTPGNTSKQGDPSKNS MTLDLNSSSKCDDSFGCSSNSSNAVIPSDETVFTPVEEKCRLDVNTELNSSIEDLLEASM PSSDTTVTFKSEVAVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQD ALPIVPQLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQA QDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYN LFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDST GQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAII EMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSR ELLKHPVFRTTW |
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| Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
| TEP | EXP Info | ||||
| Pathways | |||||
| KEGG Pathway | MAPK signaling pathway | ||||
| Ubiquitin mediated proteolysis | |||||
| RIG-I-like receptor signaling pathway | |||||
| Neurotrophin signaling pathway | |||||
| GnRH signaling pathway | |||||
| Hepatitis B | |||||
| HTLV-I infection | |||||
| PANTHER Pathway | Angiogenesis | ||||
| Apoptosis signaling pathway | |||||
| T cell activation | |||||
| Ras Pathway | |||||
| Pathway Interaction Database | Fc-epsilon receptor I signaling in mast cells | ||||
| BCR signaling pathway | |||||
| p38 MAPK signaling pathway | |||||
| CD40/CD40L signaling | |||||
| Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) | |||||
| Osteopontin-mediated events | |||||
| TRAIL signaling pathway | |||||
| CDC42 signaling events | |||||
| FAS (CD95) signaling pathway | |||||
| Role of Calcineurin-dependent NFAT signaling in lymphocytes | |||||
| TNF receptor signaling pathway | |||||
| Ceramide signaling pathway | |||||
| IFN-gamma pathway | |||||
| ErbB1 downstream signaling | |||||
| JNK signaling in the CD4+ TCR pathway | |||||
| Caspase Cascade in Apoptosis | |||||
| Regulation of cytoplasmic and nuclear SMAD2/3 signaling | |||||
| RAC1 signaling pathway | |||||
| PathWhiz Pathway | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine | ||||
| Intracellular Signalling Through Adenosine Receptor A2b and Adenosine | |||||
| Reactome | Mal cascade initiated on plasma membrane | ||||
| FCERI mediated MAPK activation | |||||
| TRAF6 mediated NF-kB activation | |||||
| TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | |||||
| MyD88 cascade initiated on plasma membrane | |||||
| WikiPathways | Serotonin HTR1 Group and FOS Pathway | ||||
| DNA Damage Response (only ATM dependent) | |||||
| Interferon type I signaling pathways | |||||
| Insulin Signaling | |||||
| EGF/EGFR Signaling Pathway | |||||
| MAPK Cascade | |||||
| p38 MAPK Signaling Pathway | |||||
| Apoptosis Modulation by HSP70 | |||||
| MAPK Signaling Pathway | |||||
| FAS pathway and Stress induction of HSP regulation | |||||
| MyD88 cascade initiated on plasma membrane | |||||
| Cardiac Hypertrophic Response | |||||
| MyD88 dependent cascade initiated on endosome | |||||
| Mal cascade initiated on plasma membrane | |||||
| Fc epsilon receptor (FCERI) signaling | |||||
| Structural Pathway of Interleukin 1 (IL-1) | |||||
| Polycystic Kidney Disease Pathway | |||||
| Apoptosis | |||||
| PDGF Pathway | |||||
| BDNF signaling pathway | |||||
| TNF alpha Signaling Pathway | |||||
| IL-1 signaling pathway | |||||
| RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | |||||
| References | |||||
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