| Drug General Information |
| Drug ID |
D0C1SE
|
| Former ID |
DNC004343
|
| Drug Name |
1,2,3,4-Tetrahydro-pyrazino[1,2-a]indole
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C11H12N2
|
| Canonical SMILES |
C1CN2C(=CC3=CC=CC=C32)CN1
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| InChI |
1S/C11H12N2/c1-2-4-11-9(3-1)7-10-8-12-5-6-13(10)11/h1-4,7,12H,5-6,8H2
|
| InChIKey |
AEIDURNZWCNQIM-UHFFFAOYSA-N
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| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Alpha-2A adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Amine oxidase [flavin-containing] A |
Target Info |
Inhibitor |
[1]
|
| Amine oxidase [flavin-containing] B |
Target Info |
Inhibitor |
[1]
|
| 5-hydroxytryptamine 2A receptor |
Target Info |
Inhibitor |
[2]
|
| Alpha-2B adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
| Alpha-2C adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
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BioCyc Pathway
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Superpathway of tryptophan utilization
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Dopamine degradation
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Putrescine degradation III
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Noradrenaline and adrenaline degradation
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Serotonin degradation
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Superpathway of melatonin degradation
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Melatonin degradation IIPWY66-401:Superpathway of tryptophan utilization
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Tryptophan degradation via tryptamine
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KEGG Pathway
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cGMP-PKG signaling pathway
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Neuroactive ligand-receptor interactionhsa00260:Glycine, serine and threonine metabolism
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Arginine and proline metabolism
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Histidine metabolism
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Tyrosine metabolism
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Phenylalanine metabolism
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Tryptophan metabolism
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Drug metabolism - cytochrome P450
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Metabolic pathways
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Serotonergic synapse
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Dopaminergic synapse
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Cocaine addiction
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Amphetamine addiction
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Alcoholismhsa00260:Glycine, serine and threonine metabolism
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Alcoholismhsa04020:Calcium signaling pathway
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Neuroactive ligand-receptor interaction
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Gap junction
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Inflammatory mediator regulation of TRP channelshsa04022:cGMP-PKG signaling pathway
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Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
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NetPath Pathway
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IL4 Signaling Pathway
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PANTHER Pathway
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Alpha adrenergic receptor signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
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5-Hydroxytryptamine degredation
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Dopamine receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
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Dopamine receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Pathway Interaction Database
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Alpha-synuclein signaling
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PathWhiz Pathway
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Histidine Metabolism
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Tyrosine Metabolism
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Glycine and Serine Metabolism
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Reactome
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Adrenoceptors
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Adrenaline signalling through Alpha-2 adrenergic receptor
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Adrenaline,noradrenaline inhibits insulin secretion
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G alpha (i) signalling events
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G alpha (z) signalling events
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Surfactant metabolismR-HSA-181430:Norepinephrine Neurotransmitter Release CycleR-HSA-390666:Serotonin receptors
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G alpha (q) signalling eventsR-HSA-390696:Adrenoceptors
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G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
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Surfactant metabolism
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WikiPathways
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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Platelet Aggregation (Plug Formation)
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Integration of energy metabolism
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GPCR ligand binding
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GPCR downstream signalingWP706:SIDS Susceptibility Pathways
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Biogenic Amine Synthesis
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Oxidative Stress
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Dopamine metabolism
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Phase 1 - Functionalization of compounds
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Neurotransmitter Release Cycle
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Neurotransmitter Clearance In The Synaptic Cleft
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Serotonin Transporter ActivityWP465:Tryptophan metabolism
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Phase 1 - Functionalization of compoundsWP733:Serotonin Receptor 2 and STAT3 Signaling
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Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
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SIDS Susceptibility Pathways
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Gastrin-CREB signalling pathway via PKC and MAPK
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GPCR downstream signaling
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GPCRs, OtherWP58:Monoamine GPCRs
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GPCR downstream signalingWP58:Monoamine GPCRs
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| References |
| REF 1 | Bioorg Med Chem Lett. 2004 Feb 23;14(4):1003-5.Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands. |
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| REF 2 | Bioorg Med Chem Lett. 2002 Jan 21;12(2):155-8.Evaluation of isotryptamine derivatives at 5-HT(2) serotonin receptors. |
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