Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0DI0B
|
||||
| Former ID |
DIB000757
|
||||
| Drug Name |
OX 19
|
||||
| Synonyms |
Sublingual desmopressin
|
||||
| Indication | Urinary incontinence [ICD9: 788.3; ICD10:N39.3, N39.4, R32] | Discontinued in Phase 1 | [1] | ||
| Company |
Orexo
|
||||
| Target and Pathway | |||||
| Target(s) | Vasopressin V2 receptor | Target Info | Agonist | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Vasopressin-regulated water reabsorption | |||||
| Pathway Interaction Database | Arf6 trafficking events | ||||
| PathWhiz Pathway | Vasopressin Regulation of Water Homeostasis | ||||
| Reactome | Vasopressin-like receptors | ||||
| G alpha (s) signalling events | |||||
| Vasopressin regulates renal water homeostasis via Aquaporins | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Regulation of Water Balance by Renal Aquaporins | |||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021110) | ||||
| REF 2 | Investigation of mechanism of desmopressin binding in vasopressin V2 receptor versus vasopressin V1a and oxytocin receptors: molecular dynamics simulation of the agonist-bound state in the membrane-aqueous system. Biopolymers. 2006 Apr 5;81(5):321-38. | ||||
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