Drug General Information
Drug ID	D0F1VQ
Former ID	DIB003966
Drug Name	ZIFROSILONE
Synonyms	MDL-73745; Zifrosilone < Rec INN; 2,2,2-Trifluoro-1-[3-(trimethylsilyl)phenyl]ethanone
Drug Type	Small molecular drug
Indication	Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10:F01-F07, F04, F05, R41.3]		Discontinued in Phase 2	[545006]
Structure		Download 2D MOL 3D MOL
Formula	C11H13F3OSi
Canonical SMILES	C[Si](C)(C)C1=CC=CC(=C1)C(=O)C(F)(F)F
InChI	1S/C11H13F3OSi/c1-16(2,3)9-6-4-5-8(7-9)10(15)11(12,13)14/h4-7H,1-3H3
InChIKey	GAPOASFZXBWUGS-UHFFFAOYSA-N
CAS Number	CAS 132236-18-1
PubChem Compound ID	60811
PubChem Substance ID	8187068, 12014573, 15122083, 43118150, 47208022, 49968648, 50947188, 57314125, 104321701, 117502557, 126422385, 127926564, 135017272, 137264028, 179149814, 194147784, 198966611, 225025325, 226553394, 241031583
Target and Pathway
Target(s)	Acetylcholinesterase	Target Info	Inhibitor	[533665], [551871]
KEGG Pathway	Glycerophospholipid metabolism
	Cholinergic synapse
PANTHER Pathway	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
	Muscarinic acetylcholine receptor 2 and 4 signaling pathway
	Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database	ATF-2 transcription factor network
PathWhiz Pathway	Phospholipid Biosynthesis
WikiPathways	Monoamine Transport
	Biogenic Amine Synthesis
	Acetylcholine Synthesis
	Integrated Pancreatic Cancer Pathway
References
Ref 545006	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001855)
Ref 533665	Acetylcholinesterase inhibition by zifrosilone: pharmacokinetics and pharmacodynamics. Clin Pharmacol Ther. 1995 Jul;58(1):54-61.
Ref 551871	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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