Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0F4FK
|
||||
| Former ID |
DIB020128
|
||||
| Drug Name |
KB-R7943
|
||||
| Drug Type |
Small molecular drug
|
||||
| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C17H21N3O6S2
|
||||
| InChI |
InChI=1S/C16H17N3O3S.CH4O3S/c17-16(18)23-10-9-12-3-7-15(8-4-12)22-11-13-1-5-14(6-2-13)19(20)21;1-5(2,3)4/h1-8H,9-11H2,(H3,17,18);1H3,(H,2,3,4)
|
||||
| InChIKey |
WGIKEBHIKKWJLG-UHFFFAOYSA-N
|
||||
| PubChem Compound ID | |||||
| PubChem Substance ID |
14782932, 24126784, 26759016, 44859801, 53787240, 53800721, 57373438, 79464357, 91746340, 135698241, 152079652, 152258706, 152344476, 160647542, 160821209, 162022899, 162249106, 163300006, 163374669, 163687832, 172844987, 175612701, 178101049, 184559922, 186014463, 204398567, 206251943, 208264937, 223393652, 227029080, 241182266, 242060122, 252215637, 252316128, 252433933, 252553669
|
||||
| Target and Pathway | |||||
| Target(s) | Short transient receptor potential channel 6 | Target Info | Blocker (channel blocker) | [2] | |
| TRP cation channel C5 | Target Info | Blocker (channel blocker) | [3] | ||
| Short transient receptor potential channel 3 | Target Info | Blocker (channel blocker) | [4] | ||
| PANTHER Pathway | Alzheimer disease-presenilin pathwayP00004:Alzheimer disease-presenilin pathway | ||||
| Pathway Interaction Database | Endothelins | ||||
| Nephrin/Neph1 signaling in the kidney podocyte | |||||
| EPO signaling pathway | |||||
| PAR1-mediated thrombin signaling eventspi3kplctrkpathway:Trk receptor signaling mediated by PI3K and PLC-gamma | |||||
| Reactome | Effects of PIP2 hydrolysis | ||||
| TRP channels | |||||
| Role of second messengers in netrin-1 signalingR-HSA-3295583:TRP channels | |||||
| Role of second messengers in netrin-1 signalingR-HSA-114508:Effects of PIP2 hydrolysis | |||||
| Role of second messengers in netrin-1 signaling | |||||
| WikiPathways | Primary Focal Segmental Glomerulosclerosis FSGS | ||||
| Platelet homeostasis | |||||
| Netrin-1 signaling | |||||
| GPCR downstream signaling | |||||
| Effects of PIP2 hydrolysisWP1868:Netrin-1 signalingWP1885:Platelet homeostasis | |||||
| Effects of PIP2 hydrolysis | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4232). | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 491). | ||||
| REF 3 | The Na+/Ca2+ exchange inhibitor KB-R7943 potently blocks TRPC channels. Biochem Biophys Res Commun. 2007 Sep 14;361(1):230-6. Epub 2007 Jul 16. | ||||
| REF 4 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 488). | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.